http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063317-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| filingDate | 2007-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c48ed329ccf7ec7a0f53dd45a5ae2cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebb85fb73e13f4858dcab2230483b308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d68990d50be7a74c56ff788889322090 |
| publicationDate | 2009-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063317-A1 |
| titleOfInvention | DRYED FORMULATION BY SPRAY |
| abstract | Pharmaceutical compositions comprising a low water soluble ionizable drug, a cationic species and a dispersion polymer are described, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg / ml in aqueous solution at a pH value between 6 and 7, (ii) a solubility of less than 20 mg / ml in a volatile organic solvent, and ( iii) an acidic pKa value greater than 5, at least 90% by weight of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species and the dispersion polymer constitute at least 80% by weight of the solid dispersion. Claim 11: The solid dispersion of any of the preceding claims, characterized in that said drug is 6-amino-9-benzyl-8-oxo-8,9-dihydro-7H-purine-2-carboxylic acid cyclopropylmethyl amide. Claim 12: The solid dispersion of any of the preceding claims, characterized in that said drug is 4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydro-imidazo [4,5-c] pyridine-2-one. Claim 13: The solid dispersion of any of the preceding claims, characterized in that said drug is 6- (5-chloro-3-methyl-benzofuran-2-sulfonyl) -2H-pyridazin-3-one. |
| priorityDate | 2006-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.