http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063275-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cdf03e8fb140a101ff7f9de9652c5fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D411-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| filingDate | 2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_062a8dace58d6db4fdd02f44e0dcb8aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_113219e5d7ed4a97e065ed513b834554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7203dd9dcfced27ab8269dc06dba03d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca579dce1d0dd05724fcdf6d3da64648 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_053072c97b8b077827fdc4ac6b368484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c447888be91d5694f8407fe3f0cbdfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31d414134d87882870a0acc5ce3369fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a64c69fd4f9d61a806de7023cab3bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9311149b885a356911fc3a18dfcd9c9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fca8e560fabfc36ca535ace2c5fbc3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e2980c48191cb9094fcf204231e708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_848a516fd6ddfa033b118990c0d19eea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57665997c0a71c4af2738a2471dc65a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e11af6cc24eba9cbe87e56505dd5303 |
| publicationDate | 2009-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063275-A1 |
| titleOfInvention | CARBOXAMIDE COMPOUNDS, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATED BY THE ACTIVATION OF CCR2. |
| abstract | Chemokine receptor antagonists are described herein, in particular, compounds of the formula (1) that act as CCR2 chemokine receptor antagonists, including pharmaceutical compositions and their uses in the preparation of medicaments, to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation. Claim 1: A compound of the formula (1): or a pharmaceutically acceptable salt thereof, characterized in that: R1 is hydrogen; alkyl, alkoxyalkyl, alkoxyphenyl, alkylthioalkyl, alkylamino, -SO2 (alkyl), -OR8, -N (R7) (R8), C3-6 cycloalkyl, C3-6 heterocycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl, each of which is optionally substituted with 1, 2 or 3 occurrences of R5; or R1 is optionally substituted (C1-6 alkylene) -R1a, wherein R1a is C3-6 cycloalkyl, C3-6 heterocycloalkyl, aryl or heteroaryl, each of which is optionally substituted with 1, 2 or 3 occurrences of R5; X is a direct link, C (R10) 2, NR10, N (R10) CO, N (R10) SO2, (2) which is a ring of 4, 5 or 6 members, where Z is N, CH or C (C1-3 alkyl); or X is NR10 (C1-6 alkylene), NR10 (C1-6 alkylene) SO2- or (C1-6 alkylene) SO2-, wherein (C1-6 alkylene) is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, methyl, and ethyl or (C1-6 alkylene) is geminally substituted to form a cyclopropyl ring; R2 is cycloalkyl, aryl, heterocyclic, heteroaryl, aralkyl, heteroaralkyl or aralkenyl; each of which is optionally substituted with 1, 2 or 3 occurrences of R5; Y is a direct bond, CO, SO2, NHCO, NHSO2, - C (= NR10) -, C1-4 alkylene, C1-4 alkylene-SO2-, -C (O) -C 1-4 alkylene, C3-6 cycloalkylene , arylene, heterocycloalkylene or heteroarylene; each of which is optionally substituted with 1, 2 or 3 occurrences of R5; R3 is hydrogen or -N (alkyl) 2; or alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl; each of which is optionally substituted with 1, 2 or 3 occurrences of R5; R4 is hydrogen, C1-8 alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, arylalkoxy or heteroarylalkoxy; R5, when present, represents, independently for each occurrence, hydrogen, halogen, hydroxy, alkyl, alkenyl, cycloalkyl, alkoxy, -CO2H, -CO2C1-3alkyl, -C (O) N (H) alkyl, - C (O) N (H) SO2alkyl, -O-alkylene CO2R10, cyano, oxo, aryl, heteroaryl, heterocyclic, alicyclic, CF3, O-CF3, O-CHF2, -O-aryl, -N (alkyl) C ( O) alkyl, -N (H) SO2alkyl, C1-3-S (O) 2-NH- alkyl or C1-3-C (O) -NH- alkyl; n is 0, 1 or 2; R7 is hydrogen or C1-3 alkyl; R8 is alkyl, alicyclic, aryl, heterocyclic or heteroaryl; and R10 is hydrogen, C1-2 alkyl or C1-2 alkenyl. |
| priorityDate | 2006-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.