http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063208-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a431f1e5f5bd51f2842c97425b320542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51a0c49e5390c69aa92b87c3a892344c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C335-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| filingDate | 2007-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063208-A1 |
| titleOfInvention | SELECTIVE MODULATORS OF ANDROGENIC RECEPTORS, ANALOGS AND DERIVATIVES OF THE SAME AND USES OF THE SAME |
| abstract | Claim 1: A compound represented by the structure of formula (1) wherein, X is C or N; W is Co N; X1 is N, NH, N (C1-4 alkyl), NAc, NCOOH or a bond; or X1 and X3 together with X2 and X5 to which X1 and X3 are attached, form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members; or X1 and X5 together with X2 to which X1 and X5 are attached, form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; P is H or formula (2); X2 is C1-4 alkylene, SO2, C (O), CH- [CH2- (C4-8 ring)], CH (C1-4 alkyl), CH (NH2), CH (OH), CH (C1- haloalkyl 4), a link; or X2 and R3 together with X1, to which X2 is attached, form a ring, which is a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members; or X2 and X5 form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; X3 is C1-4 alkylene, NH, N, CH (OH), a bond, or X3 and X1 together with X2 and X5 to which X1 and X3 are attached, form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members; or X3 and X5 form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; or X3 and X4 together form a double bond or together form a saturated or unsaturated, substituted or unsubstituted ring of 3 to 6 members, X4 is O, S, SO, C (O), S (O) [= CHCH2N (CH3 ) 2], SO2 NH, NHR ', NO, C1-4 alkylene, C (OH) [CH2CH2N (CH3) 2], C [= CHCH2N (CH3) 2], PO (C1-4 alkyl), N [CH2CH2N (CH3) 2], NO [CH2CH2N (CH3) 2] or a link; or X4 and X5 together with X3, to which X4 and X5 are attached, form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; or X3 and X4 together form a double bond or together form a saturated or unsaturated, substituted or unsubstituted ring of 3 to 6 members, X5 is a carbon or X5 and X1 together with X2 to which X1 and X5 are attached, form a ring saturated or unsaturated, substituted or unsubstituted with 5 or 6 members and A is nothing; or X5 and X2 form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; or X5 and X3 form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing; or X5 and X4 together with X3, to which X5 and X4 are attached, form a saturated or unsaturated, substituted or unsubstituted ring of 5 or 6 members and A is nothing, A is nothing, H, OH, SH, NH2, alkyl C1-4, CHF2, CH2F, CF3, CN, CH2OH, CH2O (C1-4 alkyl), CH2O (C1-4 acyl), CH2CN, CH2N3, CH2NCS, CHO, C (O) O (C1-4 alkyl), CONHR ', C (O) N (R') 2, C (O) O (C1-4 alkyl), C (O) R ', CH2CF3, CF2CF3, CH2OR' CH2C (O) CH = CH2 or C (O ) CH = CH2; or A with R forms a double bond represented by formula (3); Z is H, CN, NO2, NHC (O) CH3, C1-4 alkyl, F, CI, I or Br; Y is H, C1-4 alkyl, CF3, NO2, CN, F, CI, I or Br; Q is H, CN, OH, NO2, halide, CF3, C2-6 alkenyl, C2-6 alkynyl, C (O) CH2NH2, C (O) NH (C1-4 alkyl), C (O) N (C1 alkyl -4) 2, C (O) NH2, NH (C1-4 alkyl), NHC (O) NH (C1-4 alkyl), CH2C (O) NH2, NHC (O) NH2, NHCO (C1-4 alkyl) , NHSO2 (C1-4 alkyl), O- [CH2CH2CH (CH3) 2], O- [CH2CH2 (C4-8 cycloalkyl)], O- [CH2CH2 (C4-8 heterocycloalkyl)] or O- [CH2CH2N (CH3) 2]; R is H, OH, C1-4 alkyl, CF3, CH2OH, O (C1-4 alkyl) or O (C1-4 acyl); R1 is H, OH, NH2, F, CI, Br or I; R2 is H, benzyl substituted with R6, (CH2) 2-O-p-cyanophenyl, CH2-O-p-cyanophenyl, or CH = CH-O-p-cyanophenyl; R3 is H, C1-4 alkyl, halide, CN, NO2 or R3 and X2 together with the benzene ring to which R3 is attached and X1 to which X2 is attached form a ring, which is a saturated or unsaturated ring, substituted or not substituted of 5 or 6 members; R 'is NH2, OH or CH3; R4 and R5 are independently H, CH3, halide, OH, C1-4 alkyl, C1-6 cycloalkyl, halo (C1-4 alkyl), phenyl, aryl, C4-8 heterocycloalkyl, or hydroxy (C1-4 alkyl); R6 is CN, NO2, NHC (O) CH3 or halide; where, if P is formula (2), X is C, X1 is NH, X2 is C (O), X3 is CH2, R is OH and A is alkyl or haloalkyl, then X4 is S (O) [= CHCH2N ( CH3) 2], C (OH) [CH2CH2N (CH3) 2], C [= CHCH2N (CH3) 2], N [CH2CH2N (CH3) 2], P (O) (C1-4 alkyl) or N (O ) [CH2CH2N (CH3) 2]; or if P is formula (2), X is C, X1 is NH, X2 is C (O), X3 is CH2, R is OH or OAIk and X4 is O, S, NH, S, SO, SO2 or alkylene, then A is Cn, CH2OH, CH2O (C1-4 alkyl), CH2O (C1-4 acyl), CH2CN, CH2N3, CH2NCS, CHO, C (O) O (C1-4 alkyl), CONHR ', C (O ) N (R ') 2, C (O) O (C1-4 alkyl), C (O) R', CH2OR ', CH2C (O) CH = CH2 or C (O) CH = CH2; or if P is phenyl, X is C, X1 is NH, X2 is C (O), R is OH and A is COOH, X3 is a bond, X4 is CH2, R1, R2 is H then Q is not H, or if P is formula (2), X is C, X3 is CH2, X4 is O, or NH, R1, R2 and R3 are H, and X5 and X1 form a 5-membered ring, an oxazolidin-2-one then Q it is not halogen, or H; or if P is H, X is C, X1 is NH, X2 is C (O), R is OH, A is alkyl, X3 is a bond or CH2 and X4 is a bond or CH2, R1 and R2 are H, then Q is not H or halogen or if P is Formula (2), R3 is H, X and W are C, X1 and X5 together with X2 to which X1 and X5 are attached, form an oxazolidinedione, R is alkyl, X3 is CH2 and X4 is O, NH, S, SO2, or CH2 so Q is not a halide. |
| priorityDate | 2006-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 57.