http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063121-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| filingDate | 2007-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063121-A1 |
| titleOfInvention | PHARMACEUTICAL COMPOSITION |
| abstract | A kit and an implant device. Deposit formulations are useful for the treatment and prevention of proliferative diseases, including cancer. Claim 1: Microparticles comprising a low solubility salt of a bisphosphonate of the compound of the formula (1): wherein: X is hydrogen, hydroxyl, amino, alkanoyl, or an amino group substituted by alkyl of 1 to 4 carbon atoms , or alkanoyl; R is hydrogen or alkyl of 1 to 4 carbon atoms; and Rx is a side chain containing an optionally substituted amino group, or a nitrogen containing heterocycle (including aromatic nitrogen containing heterocycles), or a pharmaceutically acceptable salt thereof or any hydrate thereof, embedded in a polymer matrix, wherein the pharmaceutically acceptable salt thereof is selected from calcium, magnesium, and zinc; and a polymer matrix. Claim 7: A pharmaceutical composition, which comprises microparticles of any of the preceding claims, and a water based vehicle comprising a wetting agent. Claim 20: A process for the preparation of microparticles according to claim 1, which comprises the steps of: (a) preparing an internal organic phase, which comprises dissolving the polymer or polymers in a solvent or mixture of organic solvents suitable, and optionally dissolve / disperse an agent with influence on the porosity in the solution, or add a basic salt to the solution to form a polymer solution; (b) add a surfactant, and suspend the bisphosphonate in the polymer solution, or dissolve the compound of the invention in a solvent miscible with the solvent used in step (a), and mix this solution with the polymer solution, or directly dissolve the compound of the compound of the invention in the polymer solution; (c) of an external aqueous phase comprising preparing a regulator to adjust the pH to 3.0-5.0, for example, an acetate regulator, and dissolving a stabilizer; (d) mixing the internal with external organic phase to form an emulsion; (e) harden the microparticles by solvent or solvent extraction; and (f) wash, collect and dry the microparticles. |
| priorityDate | 2006-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.