http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063081-A1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
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| filingDate | 2007-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063081-A1 |
| titleOfInvention | DERIVATIVES OF 3- AZA- BICYCLE [3.1.0] HEXANE AND ITS USE FOR THE PREPARATION OF MEDICINES |
| abstract | Compounds of 3-aza-bicyclo [3.1.0] hexane and its use in the preparation of medicines. These compounds are useful in sleep disorders, such as insomnia, sleep apicea, neuropathic pain and neurological and psychiatric disorders. Claim 1: A compound of formula (1) wherein X represents C (O) or SO2; A represents aryl or heterocyclyl, where the aryl or heterocyclyl is not substituted or is independently mono- or di-substituted, where the substituents are independently selected from the group consisting of C1-4 alkyl, C3-6 cycloalkyl, C2-6 alkynyl, hydroxyC 1-4 alkyl, hydroxyC2-6 alkynyl, trimethylsilyl ethynyl, C3-6 cycloalkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy, NR2R3, N (R2) C (O) R3, C (O) NR2R3 and halogen; B represents a hydrogen atom or an aryl or heterocyclyl group, where the aryl or heterocyclyl is not substituted or is independently mono-, di- or trisubstituted, where the substituents are independently selected from the group consisting of C1-4 alkyl, C3 cycloalkyl -6, C1-4 alkoxy, rnethoxy-C1-4 alkoxy, cyano, trifluoromethyl, trifluoromethoxy, NR2R3, N (R2) C (O) R3, C (O) NR2R3 and halogen; or B represents a 2,3-dihydro-benzo [1,4] dioxinyl group; or A and B together represent a tricyclic group; n represents 0 or 1; R1 represents aryl or heterocyclyl, where the aryl or heterocyclyl is not substituted is independently mono-, di- or tri-substituted, where the substituents are independently selected from the group consisting of C1-4 alkyl, C2-6 alkynyl, C3- cycloalkyl 6, C1-4 alkoxy, C1-4 alkylthio, halogen, hydroxy, cyano, trifluoromethyl, trifluoromethoxy, NR2R3, N (R2) C (O) R3, COOR2 and C (O) NR2R3, or R1 represents a heterocyclyl group -etenyl, heterocyclyl-C1-4alkyl or aryloxyalkylC 1-4, wherein said groups are not substituted or are independently mono- or di-substituted in the aryl or heterocyclyl moiety, where the substituents are independently selected from the group consisting of C1-alkyl -4, C1-4 alkoxy, halogen, trifluoromethyl, trifluoromethoxy and NR2R3, or R1 represents a 2,3-dihydro-benzofuranyl, benzo [1,3jioxolyl, 2,3-dihydro-benzo [1,4] dioxinyl, 4 group -oxo- 4H-chromenyl, 2H-chromenyl, chromanyl, 4H-benzo [1,3] dioxinyl, 2,3-dihydro-thieno [3,4-b] [1,4] di oxinyl, morpholin-4-yl-phenyl, piperazin-1-yl-phenyl, 3,4-dihydro-2H-benzo [1,4] oxazinyl, 3-oxo-3,4-dihydro-2H-benzo [1, 4] oxazinyl or 2,3,6,7-tetrahydrobenzo [1,2-b; 4,5-b '] difuranyl, wherein said groups are not substituted or are independently mono- or di-substituted, where the substituents they are independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy and halogen; R2 represents hydrogen or C1-4 alkyl; and R3 represents hydrogen or C1-4 alkyl; or a pharmaceutically acceptable salt of said compound. |
| priorityDate | 2006-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 63.