http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063059-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f874eb11d4775decc4fd06a6071a4c9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 |
| filingDate | 2007-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063059-A1 |
| titleOfInvention | DERIVATIVES OF QUINOLINONA AND 1,8-NAFTIRIDINONE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES AS ANTI-HIV AGENTS. |
| abstract | Claim 1: A compound of formula (1); including stereoisomeric forms, pharmaceutically acceptable salts and pharmaceutically acceptable solvates of said compound; where R1 is cyano; R 2 is H, C 1-6 alkyl, trifluoromethyl, amino, mono- or di-C 1-6 alkyl, C 1-6 alkyl where the C 1-6 alkyl group is substituted with hydroxy, amino, C 1-6 alkylcarbonylamino-, mono- or C 1-6 dialkyl-, pyridyl, imidazolyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, 4-C 1-6 alkylpiperazinyl, or with 4- (C 1-6 alkylcarbonyl) piperazinyl; X1 is CH or N; R3 is phenyl or pyridyl, each of which may not be substituted or substituted with one or two substituents, each of which is independently selected from C1-6 alkyl, C1-6 alkoxy, nitro, cyano, halo, trifluoromethyl , or R3 is benzoxadiazole, or benzoxazolone N-substituted with C1-6 alkyl; R 4 is H, C 1-6 alkyl, (C 1-6 alkylcarbonylamino) C 1-6 alkyl, Ar, thienyl, thienyl substituted with carboxyl, furanyl, pyridyl, pyrimidyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, thiazolyl, halo, trifluoromethyl, hydroxy, C1-6 alkyloxy, -OPO (OH) 2, amino, aminocarbonyl, cyano, a radical of the formula -Y1-R6, -Y1-Alq-R6, or of the formula -Y1-Alq-Y2- R7; R5 is H, halo, hydroxy or C1-6 alkyloxy or R4 and R5 taken together form a bivalent radical -O-CH2-O-; Y1 is O or NR8; Y2 is O or NR9; Alq is bivalent C1-6 alkyl; R 6 is pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, 4-C 1-6 alkylpiperazinyl, 4- (C 1-6 alkylcarbonyl) piperazinyl, pyridyl or imidazolyl; R 7 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkylcarbonyl; R8 is H or C1-6 alkyl; R9 is H or C1-6 alkyl; Ar is phenyl optionally substituted with one, two or three substituents, each of which is independently selected from C1-6 alkyl, halo, hydroxy, mono- or dialkyl C1-6 amino, carboxyl, C1-6 alkylcarbonylamino, aminocarbonyl, mono - or C1-6 dialkylcarbonylalkyl, and C1-6 alkyl substituted with amino, hydroxy, mono- or di-C1-6 alkyl, C1-6 alkylcarbonylamino, [(mono- or C1-6 dialkyl) amino-C1-6 alkyl] carbonylamino, or with C1-6 alkyl sulfonylamino. |
| priorityDate | 2006-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.