http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-062485-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ce023a6c13740cb05a67332f11a29f9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2982 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-44 |
| filingDate | 2007-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-062485-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF A SODIUM SALT OF IBUPROFEN OF DIFFERENT SIZES OF PARTICULATE |
| abstract | A fluid hydrated ibuprofen sodium salt of medium particle size and controlled water content is provided. It can be produced by adding aqueous NaOH to a solution or suspension of unboiled ibuprofen in an organic solvent that can be distilled together with water at a temperature in the range between 50 and 120 ° C. The rate of addition of NaOH is such that it does not cause the resulting reaction mixture to boil before the addition is complete. After the addition is complete, the water is removed with part of the organic solvent by distillation. After cooling, the hydrated ibuprofen sodium salt is recovered from the resulting suspension. The process allows to control the average particle size of the ibuprofen sodium salt formed by selecting and using a predetermined effective concentration of NaOH in the aqueous NaOH solution used. |
| priorityDate | 2006-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.