http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-062421-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 |
filingDate | 2007-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2008-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | AR-062421-A1 |
titleOfInvention | PROCESS TO RESOLVE PIPERIDIN CHIRAL ALCOHOL AND PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 'PIRAZOLO [1,5-A] PYRIMIDINE USING THE SAME |
abstract | Claim 1: A process for resolving the S-isomer of 2-piperidin-2-yl ethanol from a mixture of isomers, the process comprising: (a) combining a solution comprising an aprotic, polar organic solvent and a mixture of 2-piperidin-2-yl-ethanol isomers with an aliphatic alcohol solution containing an amino acid resolving agent selected from N-acetyl-L-leucine and N-acetyl-L-methionine; (b) mixing the combined solutions with additional amounts of the aprotic, polar organic solvent and warm the mixture to a temperature below the boiling point of any solvent in the mixture sufficient to promote the dissolution of any of the solids present in the mixture; (c) cooling the mixture to a temperature that allows salt to precipitate therefrom; (d) optionally isolating the precipitated salt formed in stage ôc '; and (e) optionally purifying the isolated salt from the ôdö stage by recrystallization or suspension with a purification solvent. Claim 21: A process for making pyrazolo [1,5-a] pyrimidin-7-yl-amino compounds of Formula (1) wherein R2 is a linear, branched or cyclic alkyl group, the process comprising: (a) combining a solution comprising an aprotic, polar organic solvent and a mixture of 2-piperidin-2-yl-ethanol isomers with an aliphatic alcohol solution containing an amino acid resolving agent selected from N-acetyl-L-leucine and N-acetyl-L-methionine; (b) mixing the combined solutions with additional amounts of the aprotic, polar organic solvent and warm the mixture to a temperature below the boiling point of any solvent in the mixture sufficient to promote the dissolution of any of the solids present in the mixture; (c) cooling the mixture to a temperature that allows the salt of the compound (4) to precipitate therefrom; (d) isolate the precipitated salt formed in the ôcö stage; (e) purify the salt from the ôcö stage through the suspension of the salt in a mixture of acetonitrile (ACN) and methanol 10: 1 by volume; (f) releasing the free base alcohol (4) from the salt prepared in the ôeö purification stage; and (g) reacting the free base alcohol from step ôeö with the compound of the formula (5). |
priorityDate | 2006-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.