http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061944-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_382ccfc2ebebcaee15aa7cda4cee86bc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| filingDate | 2007-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4372b3b4471c3bae3ed29ced2b1abd14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceea85e269d25138c5d4e506e5ad22a6 |
| publicationDate | 2008-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061944-A1 |
| titleOfInvention | "NF-KB INHIBITOR" |
| abstract | Claim 1: A preventive or therapeutic agent for a disease associated with NF-kB comprising as an active ingredient a carbostyril compound represented by the general formula (1) or a salt thereof, wherein A is a direct bond, a group lower alkylene, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; the link between positions 3 and 4 of the carbostyril skeleton is a single bond or a double bond; R4 and R5 each represent a hydrogen atom, with the proviso that when the link between positions 3 and 4 of the carbostyryl skeleton is a double bond, R4 and R5 can instead be linked together in the form of a group -CH = CH-CH = CH-; R1 is one of the following (1-1) to (1-30); (1-1) a hydrogen atom, (1-2) a lower alkyl group, (1-3) a phenyl group lower alkyl optionally substituted on the phenyl ring with one or more members selected from the group consisting of a group phenyl, lower alkyl groups, lower alkoxy groups, halogen atoms, groups - (B) 1NR6R7, a nitro group, a carboxy group, lower alkoxycarbonyl groups, a cyano group, lower alkoxy phenyl groups, a phenoxy group, piperidinyl lower alkoxycarbonyl groups , lower amino alkoxycarbonyl groups optionally substituted with one or more cycloalkyl groups, 2-imidazolinylcarbonyl groups optionally substituted on the 2-imidazoline ring with one or more lower alkylthio groups, 3-pyrrolinylcarbonyl groups optionally substituted on the 3-pyrroline ring with one or more lower alkyl groups, thiazolidinylcarbonyl groups optionally substituted on the thiazolidine ring with a phenyl group, 3-azabicyclo [3.2.2] nonylcarbonyl groups, groups piperidinyl lower alkyl, lower alkyl anilino groups optionally substituted in the amino group with one or more lower alkyl groups, phenylthio lower alkyl groups, indolinyl lower alkyl groups, and piperidinylcarbonyl groups optionally substituted on the piperidine ring with one or more lower alkyl groups, ( 1-4) a lower alkyl cycloalkyl group, (1-5) a lower alkyl phenoxy group, (1-6) a lower alkyl naphthyl group, (1-7) a lower alkyl lower alkoxy group, (1-8) a lower alkyl carboxy group, (1-9) a lower alkyl lower alkoxycarbonyl group, (1-10) a lower alkyl pyridyl group optionally substituted on the pyridine ring with one or more members selected from the group consisting of halogen atoms; piperidinyl groups; a morpholino group; Piperazinyl groups optionally substituted on the piperazine ring with one or more members selected from the group consisting of a phenyl group and a lower alkyl group; thienyl groups; a phenyl group; pyridyl groups; piperidinyl lower alkyl groups; phenylthio lower alkyl groups; biphenyl groups; lower alkyl groups optionally substituted with one or more halogen atoms; pyridylamino groups; pyridylcarbonylamino groups; lower alkoxy groups; lower alkyl anilino groups optionally substituted in the amino group with one or more lower alkyl groups; and aniline groups optionally substituted in the amino group with one or more lower alkyl groups, (1-11) a cyano lower alkyl group, (1-12) a -A1-CONR8R9 group, (1-13) a group of the formula (2); (1-14) a phenyl group, (1-15) a lower alkyl quinolyl group, (1-16) a lower alkoxy lower alkyl group substituted with lower alkoxy, (1-17) a lower alkyl group substituted with hydroxy, ( 1-18) a lower alkyl thiazolyl group optionally substituted on the thiazole ring with one or more members selected from the group consisting of halogen atoms, a phenyl group, thienyl groups and pyridyl groups, (1-19) a lower alkyl group optionally substituted with one or more halogen atoms, (1-20) a lower alkyl lower alkylsilyloxy group, (1-21) a lower alkyl phenoxy group optionally substituted on the phenyl ring with one or more members selected from the group consisting of lower alkyl groups optionally substituted with one or more halogen atoms; lower alkoxy groups; halogen atoms; lower alkenyl groups; cycloalkyl groups; a nitro group; and a phenyl group, (1-22) a phenylthio lower alkyl group optionally substituted on the phenyl ring with one or more halogen atoms, (1-23) a lower piperidinyl alkyl group optionally substituted on the piperidine ring with one or more members selected from the group consisting of phenyl lower alkyl groups and a phenyl group, (1-24) a lower alkyl piperazinyl group optionally substituted on the piperazine ring with one or more phenyl groups, (1-25) a 1,2 group, 3,4-tetrahydroisoquinolyl lower alkyl, (1-26) a naphthyloxy lower alkyl group, (1-27) a benzothiazolyloxy lower alkyl group optionally substituted on the benzothiazole ring with one or more alkyl groups, (1-28) an alkyl group lower substituted with one or more members selected from the group consisting of quinolyloxy groups and isoquinolyloxy groups, (1-29) a lower alkyl pyridyloxy group optionally substituted on the pyridine ring with one or more alk groups lower uyl, (1-30) a lower alkenyl; R2 is one of the following (2-1) to (2-33), (2-1) a hydrogen atom, (2-2) a lower alkoxy group, (2-3) a lower alkyl group, (2 -4) a lower alkoxy carboxy group, (2-5) a lower alkoxycarbonyl group lower alkoxy, (2-6) a hydroxy group, (2-7) a lower alkoxy phenyl group optionally substituted on the phenyl ring with one or more members selected from the group consisting of halogen atoms, lower alkyl groups optionally substituted with one or more halogen atoms; lower alkylthio groups optionally substituted with one or more halogen atoms; lower alkoxy groups; a nitro group; lower alkylsulfonyl groups; lower alkoxycarbonyl groups; lower alkenyl phenyl groups; lower alkanoyloxy groups; and 1,2,3-thiadiazolyl groups, (2-8) a lower alkoxy piperidinyl group optionally substituted on the piperidine ring with one or more lower alkyl groups, (2-9) an amino-substituted lower alkoxy group optionally substituted with one or more lower alkyl groups, (2-10) a lower alkenyloxy group, (2-11) a lower alkoxy pyridyl group optionally substituted on the pyridine ring with one or more lower alkyl groups, each lower alkyl substituent being optionally substituted with one or more halogen atoms, (2-12) a lower alkynyloxy group, (2-13) a lower alkynyloxy phenyl group, (2-14) a lower alkenyloxy phenyl group, (2-15) an optionally substituted lower alkoxy furyl group in the furan ring with one or more lower alkoxycarbonyl groups, (2-16) a lower alkoxy tetrazolyl group optionally substituted on the tetrazol ring with a member selected from the group consisting of a phenyl group, alkyl phenyl groups or lower, and lower alkyl cycloalkyl groups, (2-17) a 1,2,4-oxadiazolyl lower alkoxy group optionally substituted on the 1,2,4-oxadiazole ring with a phenyl group, the phenyl substituent being optionally substituted on the phenyl ring with one or more lower alkyl groups, (2-18) a lower alkoxy isoxazolyl group optionally substituted on the isoxazol ring with one or more lower alkyl groups, (2-19) a lower alkoxy 1,3,4-oxadiazolyl group optionally substituted on the 1,3,4-oxadiazole ring with a phenyl group, the phenyl substituent being optionally substituted on the phenyl ring with one or more lower alkyl groups, (2-20) a lower alkoxy lower alkoxy group, (2- 21) a thiazolyl lower alkoxy group optionally substituted on the thiazole ring with one or more members selected from the group consisting of lower alkyl groups and a phenyl group, each phenyl substituent being optionally substituted on the feni ring it with one or more halogen atoms, (2-22) a piperidinyloxy group optionally substituted on the piperidine ring with one or more benzoyl groups, each benzoyl substituent being optionally substituted on the phenyl ring with one or more halogen atoms, (2 - 23) a lower alkoxy thienyl group, (2-24) a lower alkoxy phenylthio group, (2-25) a substituted lower alkoxy carbamoyl group, optionally substituted with one or more lower alkyl groups, (2- 26) a lower alkoxy benzoyl group, (2-27) a lower alkoxy pyridylcarbonyl group, (2-28) a lower alkoxy imidazolyl group optionally substituted on the imidazole ring with one or more lower alkyl phenyl groups, (2-29) a alkoxy phenoxy group lower, (2-30) a lower alkoxy phenyl group substituted with lower alkoxy, (2-31) a 2,3-dihydro-1H-indenyloxy group, (2-32) a lower alkoxy isoindolinyl group optionally substituted on the isoindoline ring with one or more oxo groups, (2-33) a phenyl group; R3 is one of the following (3-1) to (3-19); (3-1) a hydrogen atom, (3-2) a lower alkyl group, (3-3) a hydroxy-substituted lower alkyl group, (3-4) a lower alkyl cycloalkyl group, (3-5) a lower alkyl carboxy group, (3-6) a lower alkyl lower alkoxycarbonyl group, (3-7) a lower alkyl phenyl group optionally substituted on the phenyl ring with one or more members selected from the group consisting of halogen atoms; lower alkyl groups optionally substituted with one or more halogen atoms; lower alkoxy groups optionally substituted with one or more halogen atoms; a phenyl group; lower alkoxycarbonyl groups; a phenoxy group; lower alkylthio groups; lower alkylsulfonyl groups; phenyl lower alkoxy groups; and optionally substituted amino groups c |
| priorityDate | 2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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