http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061858-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-650952 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6518 |
| filingDate | 2007-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c801cc2003c37f445802e07788db7747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2ffadfc910e0cfd19b5d1aaca7d819c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63c399a88187a8709ec85bcb2c517553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2584a92d398cd910920e8a4b13662caa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dc91b9d3cae805086bfc4abf28233bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cf7d2039d4204354e1e24a8d152be73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_276e8fe79c12850ae034b40d154e070d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e0420a3d3eb67058df2522fad505598 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaecc1b2aec48be0b9db48a3018dea07 |
| publicationDate | 2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061858-A1 |
| titleOfInvention | HETEROCICLICAL COMPOSTS OF PHOSPHONATES AND PHOSPHINATES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES AS ANTIDIABETIC AGENTS. |
| abstract | Claim 1: A compound characterized in that it has the structure (1) wherein R1 is a heteroaryl substituted by R4 and optionally substituted with one or two substituents R5 and R6, wherein the heteroaryl possesses a nitrogen atom adjacent to the atom that binds the group heteroaryl at -NH-C (= O); R4 is selected from the group consisting of - (CH2) nZ- (CH2) m-PO (OR7) (OR8), or - (CH2) nZ- (CH2) m-PO (OR7) R9, or - (CH2) nZ (CH2) mO-PO (OR7) R9, or - (CH2) nZ- (CH2) mO-PO (R9) R10 or - (CH2) nZ- (CH2) m- PO (R9) R10; R7 and R8 are the same or different and are independently selected from the group consisting of hydrogen and alkyl, or R7 and R8 can be cyclized in a ring of formula (2) where q = 1-3; R9 and R10 are the same or different and are independently selected from the group consisting of alkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; or R9 and R10 can be cycled into a ring of formula (3) or (4) where q = 1-3 or R7 and R9 can be cycled into a ring of formula (5) or (6) where q = 1-3; Z is selected from a bond, alkylene, alkenylene, O, S or SO2; m is 0.1 or 2, with the proviso that when Z is O, S or SO2, m is 1 or 2; n is 0, 1 or 2; R5 and R6 are the same or different and are independently selected from the group consisting of hydrogen, alkyl, halogen, or carboxyl, or is absent; X is selected from the group consisting of formulas (7) and an X-6 link; and when Y is absent, X is as in formulas (8); R2 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkynyl, and alkenyl; p is 0 or 1; Q is selected from the group consisting of O, S (O) q and CO, where q is 0, 1 or 2; Q1 is selected from the group consisting of hydrogen and fluorine; R11 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryl and heteroaryl; R12 is selected from the group consisting of hydrogen, and lower alkyl, or R11 and R12 together with the carbon atom to which they bind, form a cycloalkyl ring of 5 to 7 carbon atoms; R13 is selected from the group consisting of halo, nitro, amino, cyano, methyl, trifluoromethyl, hydroxy, methoxy, trifluoromethoxy, methylthio, methylsulfinyl or methylsulfonyl; T is selected from the group consisting of aryl and heteroaryl; Y is R3- (CH2) s-, or is absent; R3 is selected from the group consisting of aryl or heteroaryl; s = 0 or 1; all stereoisomers thereof, a prodrug ester thereof or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2006-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.