http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061850-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| filingDate | 2007-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a4117e71c4c94db246bc66405c55fae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b7f9e80ee524f54d8e453bf7ff9cfd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a1c21292e37ca5182957f94725e179f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9335805a794c9bd087e4ca225dd22bad |
| publicationDate | 2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061850-A1 |
| titleOfInvention | PIRIMIDINE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| abstract | Claim 1: A compound, characterized in that it is of formula (1) wherein R3 represents hydrogen, an optionally substituted C1-12 alkyl group, optionally substituted C2-12 alkenyl, optionally substituted C2-12 alkyl, optionally substituted C6-14 aryl, optionally substituted C3-12 cycloalkyl, optionally substituted C3-12 cycloalkenyl, optionally substituted C7-12 polycycloalkyl, optionally substituted C7-12 polycycloalkenyl, optionally substituted C5-12 spirocycloalkyl, optionally substituted 3 to 12 membered heterocycloalkyl comprising 1 or 2 heteroatoms, a optionally substituted 4 to 12-membered heterocycloalkenyl group comprising 1 or 2 heteroatoms, or an optionally substituted heteroaryl ring comprising 1, 2 or 3 heteroatoms each independently selected from nitrogen, oxygen or sulfur; R4 each independently represents -CN, hydroxy, -NR6R7, -NR6SO2R7, halogen, optionally substituted C1-6 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, C1 -5 optionally substituted, optionally substituted C3-6 cycloalkoxy, optionally substituted C2-5 alkenoxy, optionally substituted C2-5 alkynyloxy, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkylsulfoxy or optionally substituted C1-6 alkylsulfonyl, a heterocycloalkyl group 3 to 12 optionally substituted members comprising 1 or 2 heteroatoms, or an optionally substituted 3 to 12 member heterocycloalkoxy group comprising 1 or 2 heteroatoms; RN represents hydrogen, -NH2, -OH, -CN, -C = CH, -C (= O) NH2, C1-3 alkyl, C1-3 alkylamino, C1-3 alkylthio, C1-3 alkyloxy, C1-3 alkylcarbonyl , -CHO, or -SO2Me; p is 0, 1 or 2; Q is C (= X1) -NRaRb, -S (O) 2-NRa2Rb2, - (optionally substituted C1-3 alkyl) g-NRa3Rb3, - S (O) k-Ra8, C (= X2) -ORa9, - ORa10 or - (5- to 6-membered aromatic or heteroaromatic ring optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulfur) -Ln-R5m; g is 0 or 1; k is 0, 1 or 2; Ra represents H or optionally substituted C1-6 alkyl, and Rb represents - Ln-R5m, or Ra and Rb together with the nitrogen atom to which they are attached form a saturated or unsaturated 4- to 7-membered heterocyclic ring which optionally comprises 1 to 2 additional heteroatoms; Ra2 represents H or optionally substituted C1-6 alkyl, and Rb2 represents - Ln-R5m, or Ra2 and Rb2 together with the nitrogen atom to which they are attached form a saturated 4- or 7-membered saturated or unsaturated heterocyclic ring which optionally comprises 1 to 2 additional heteroatoms; Ra3 represents H or optionally substituted C1-6 alkyl, and Rb3 represents -Ln-R5m, -SO2NRa4Rb4, -C (= O) NRa5Rb5, SO2Ra6, -C (= O) ORa7, or Ra3 and Rb3 together with the nitrogen atom at which are joined together form a saturated or unsaturated 4 to 7 membered heterocyclic ring optionally comprising 1 to 2 additional heteroatoms; Ra4 represents H or optionally substituted C1-6 alkyl, and Rb4 represents - Ln-R5m, or Ra4 and Rb4 together with the nitrogen atom to which they are attached form a saturated 4- or 7-membered saturated or unsaturated heterocyclic ring which optionally comprises 1 to 2 additional heteroatoms; Ra5 represents H or optionally substituted C1-6 alkyl, and Rb5 represents - Ln-R5m, or Ra5 and Rbs5 together with the nitrogen atom to which they are attached form a saturated 4- or 7-membered saturated or unsaturated heterocyclic ring which optionally comprises 1 to 2 additional heteroatoms; Ra6 represents -Ln-R5m; Ra7 represents -Ln-R5m; Ra8 represents -Ln-R5m; Ra9 represents -Ln-R5m; Ra10 represents -Ln-R5m; L represents a connector selected from optionally substituted C2-10 alkyl, optionally substituted C2-10 alkyl, optionally substituted C6-14 aryl, optionally substituted C2-4 alkyl-C6-14 aryl, optionally substituted aryl C6-14-C1-4 alkyl , optionally substituted C3-12, optionally substituted C7-12 polycycloalkyl, optionally substituted C7-12 polycycloalkenyl, optionally substituted C5-12 spirocycloalkyl and optionally substituted heteroaryl comprising 1 or 2 nitrogen atoms; n is 0 or 1; m is 1 or 2; R5 represents a group selected from hydrogen, optionally substituted morpholinyl, optionally substituted piperidinyl, optionally substituted piperazinyl, optionally substituted piperazincarbonyl, optionally substituted pyrrolidinyl, optionally substituted tropenyl, optionally substituted dichtomethylpiperazinyl, optionally substituted thyrinyl, optionally substituted sulfonyl, optionally substituted substituted, optionally substituted granatane, optionally substituted oxogranatane and -NR8R9, R6, R7 each independently represents hydrogen or optionally substituted C1-4 alkyl; R8, R9 each independently represents hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-4 cycloalkyl, optionally substituted C3-10 cycloalkyl, optionally substituted C6-14 aryl, C1-6-aryl alkyl Optionally substituted C6-14, optionally substituted pyranyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted C1-4 alkyloxycarbonyl, optionally substituted C1-14 arylcarbonyl, optionally substituted C1-4 alkylcarbonyl, optionally substituted C6-14 aryl sulfonyl, C6-14 arylsulfonyl optionally substituted, optionally substituted C1-4 alkylsulfonyl, optionally substituted aryl C1-14-C1-4 alkylsulfonyl, or R8 and R9 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring, with or without a bridge 3 to 7 members optionally comprising 1 to 2 additional heteroatoms; X1 is O or S; X2 is O, S or H2; Ar represents a 5- to 6-membered aromatic or heteroaromatic ring optionally comprising at least one ring heteroatom selected from nitrogen, oxygen and sulfur; and A1, A2 each independently represents N or CH; and where when Z1 is C = O, Z2 is CRcRd or NRe and Z3 is CR1R2 R1, R2 each independently represents hydrogen, optionally substituted C1-4 alkyl or optionally substituted C3-6 cycloalkyl, or R1 and R2 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 to 6 members optionally comprising 1 to 2 heteroatoms; Rc, Rd each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or Rc and Rd together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 a 6 members optionally comprising 1 to 2 heteroatoms; Re represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl; or optionally one of R1 and R3, or R2 and R3, or R1 and Rc, or R2 and Rd, or R1 and Re together represent a saturated or unsaturated C1-4 alkyl bridge optionally comprising 1 heteroatom; or when Z2 is C = 0, Z1 is CRf2Rg2 and Z3 is CR1R2; R1, R2 each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or R1 and R2 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 to 6 members optionally comprising 1 to 2 heteroatoms; Rf2, Rg2 each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or Rf2 and Rg2 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 a 6 members which optionally comprises 1 to 2 heteroatoms; or optionally one of R1 and R3, or R2 and R3 together represent a saturated or unsaturated C1-4 alkyl bridge optionally comprising 1 heteroatom; or when Z3 is C = O, Z2 is CRc3Rd3 or NRe3 and Z1 is CRf3Rg3; Rc3, Rd3, each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or Rc3 and Rd3 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 6-member optionally comprising 1 to 2 heteroatoms; Re3 represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl; Rf3, Rg3 each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or Rf3 and Rg3 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 a 6 members optionally comprising 1 to 2 heteroatoms; or optionally one of Rc3 and Rf3, or Rd3 and Rg3, or Re3 and Rf3 together represent a saturated or unsaturated C1-4 alkyl bridge optionally comprising 1 heteroatom or when Z1 is CRfRg, Z2 is CRcRd or Nre and Z3 is CR1R2; R1, R2 each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or R1 and R2 together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 to 6 members optionally comprising 1 to 2 heteroatoms; Rc, Rd each independently represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl, or Rc and Rd together with the carbon atom to which they are attached form a saturated or unsaturated ring of 3 a 6 members optionally comprising 1 to 2 heteroatoms; Re represents hydrogen, optionally substituted C1-6 alkyl or optionally substituted C3-6 cycloalkyl; Rf, Rg each independently represents hydrogen, optionally substituted C1-6 alkyl or cycloalkyl |
| priorityDate | 2006-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.