http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061808-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae84948901b77f34fd51c41264d8d19c |
| filingDate | 2007-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccc7703060955fd59d9aa4615795dab6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_620c276ae2697f94b9d059c956c445c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45fbbfb36f9d78d2fb17976a7272e2e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edb4694bf845f51757da453f29918ea3 |
| publicationDate | 2008-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061808-A1 |
| titleOfInvention | DERIVATIVES OF AZAINDOL WITH A COMBINATION OF PARTIAL AGONISM OF THE RECEIVER NICOTINICO ACETILCOLINA AND INHIBITION OF THE REABSORTION OF DOPAMINE |
| abstract | These compounds have a combination of partial agonism of the nicotinic acetylcholine receptor and inhibition of dopamine reabsorption. It also refers to pharmaceutical compositions containing these compounds, methods for preparing them, methods for preparing intermediate compounds useful for their synthesis, methods for preparing compositions and uses of such compounds and compositions, particularly their use in the administration to patients to achieve an effect. therapeutic in disorders in which nicotinic receptors and / or dopamine transporters are involved or that can be treated via the manipulation of such receptors. Claim 1: Compounds derived from azaindole, characterized by the general formula (1) wherein X, Y and Z independently represent N or C, with the proviso that the ring contains at least one atom of N, and not more than 2; m and n are independently either 0 (zero) or 1, with the proviso that when Y and Z represent carbon and X represents nitrogen, m is 0 (zero); R2 and R3 independently represent hydrogen, halogen, C1-3 alkyl, C1-3 alkynyl, NH-C1-3 alkyl, CF2, hydroxyl, C1-3oxy alkyl or a piperidinyl group, pyrrolidinyl, tetrahydropyridinyl, morpholinyl, azepanyl, 1-aza -bicyclo [2.2.2] octanyl or 1-aza-bicyclo [2.2.2] oct-2-enyl, a group that is either unsubstituted or substituted with one or more substituents selected from halogen, C1-3 alkyl, phenyl or benzyl; R4, R5 and R6 independently represent hydrogen, halogen, C1-3 alkyl, C2-3 alkynyl, NH-C1-3 alkyl, hydroxy or C1-3oxy alkyl, with the proviso that R4 exists only when Y = C, R5 only when Z = C; and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and their tautomers, stereoisomers and N-oxides, compounds having a combination of partial agonism of the receptor Nicotinic acetylcholine and inhibition of dopamine reabsorption. |
| priorityDate | 2006-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.