http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061296-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-04 |
| filingDate | 2007-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061296-A1 |
| titleOfInvention | PROCEDURE FOR MAKING N-HYDROXI-3- [4- [[[2- (2-METHYL-1H-INDOL-3-IL) ETHYL] AMINO] METHYL] PHENYL] -2E-2-PROPENAMIDE AND STARTING MATERIALS FOR SAME |
| abstract | The compound is useful as a histone deacetylase inhibitor, antiproliferative. Claim 1: A method of making N-hydroxy-3- [4 - [[[2- (2-methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2E-2-propenamide, which It comprises the steps of: (a) combining sodium hydroxide and the methyl ester hydrochloride salt of (E) -3- (4 - {[2- (2-methyl-1H-indole-3-yl) ethylamino acid ] -methyl] phenyl) -acrylic to form a mixture at a temperature of about -15 ° C; and subsequently (b) adding hydroxylamine to the mixture to form N-hydroxy-3- [4 - [[[2- (2-methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2E- 2-propenamide |
| priorityDate | 2006-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.