http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-061222-A1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f1a30682c7f24ace5f2b16c6be633b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0834 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| filingDate | 2007-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-061222-A1 |
| titleOfInvention | DERIVATIVES OF 2-OXO-PIRIDINA, 2-OXO-QUINOLINA AND 2-OXO-ISOQUINOLINA, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THE SAME IN MEDICATIONS TO TREAT DISEASES MEDIATED BY SCD. |
| abstract | Heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Also included are drugs that use these derivatives in order to modulate the activity of stearoyl-CoA desaturase, and pharmaceutical compositions comprising these derivatives. Claim 1: A compound of the formula (1) wherein, V is selected from -N (R5) C (O) -, -C (O) N (R5) -, -OC (O) N (R5 ) -, -N (R5) C (O) O-, -N (R5) C (O) N (R5) -, -O-, -N (R5) -, -S-, -S (O) t-, -N (R5) S (O) t, -S (O) tN (R5) -, - OS (O) 2-, -OS (O) 2N (R5) -, -C (O) - , -OC (O) -, -C (O) O-, -N (R5) C (= N (R5a)) NR5-, -N (R5) C (= S) NR5-, -N (R5) ((R5a) N =) C -, -C (= N (R5a)) N (R5) -, alkylene, alkenylene, alkynylene, aryl, heteroaryl, cycloalkyl, heterocyclyl, or a direct bond; W is selected from -N (R5) C (O) -, -C (O) N (R5) -, -OC (O) N (R5) -, -N (R5) C (O) O- , -N (R5) C (O) N (R5) -, -O-, -N (R5) -, -S-, -S (O) t-, -N (R5) S (O) t, -S (O) tN (R5) -, -OS (O) 2-N (R5), -C (O) -, -OC (O) -, -C (O) O-, -N (R5) C (= N (R5a)) NR5-, -N (R5) ((R5a) N =) C-, -C (= N (R5a)) N (R5) -, aryl, heteroaryl, heterocyclyl, alkynylene, alkenylene , alkylene, or a direct bond; X is selected from C (H) or N; Y is selected from S, O, N (H) or N (CH3); p is 0, 1, 2, or 3; t is 1 or 2; R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy-alkyl, alkoxy-alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, heterocyclyl, heterocyclyl-alkyl, heteroaryl, and heteroaryl-alkyl ; or R1 is a multi-ring structure having 2 to 4 rings, wherein the rings are independently selected from the group consisting of cycloalkyl, heterocyclyl, aryl, and heteroaryl, and where some or all rings can be fused together. with others; R2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy-alkyl, alkoxy-alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, halo-alkyl, aralkyl, heterocyclyl, heterocyclyl-alkyl, heteroaryl, and heteroarylalkyl; or R2 is a multi-ring structure having 2 to 4 rings, wherein the rings are independently selected from the group consisting of cycloalkyl, heterocyclyl, aryl, and heteroaryl, and where some or all rings can be fused together. with others; R3 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkoxy, hydroxy-alkyl, alkoxy-alkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclyl, aryl, aralkyl, heteroaryl, halogen, halo-alkyl, halo-alkoxy, cyano, and -N (R5) 2; R4 is selected from the group consisting of alkyl, hydroxy-alkyl, cycloalkyl-alkyl, aralkyl, halogen, haloalkyl, -OCF3, -OC (H) F2, and cyano; or two adjacent R4 groups, together with the carbon atoms with which they are attached, can form a cycloalkyl, heterocyclyl, aryl, or heteroaryl, and the remaining R4 groups, if present, are as described above; R5 is selected from the group consisting of hydrogen, aryl, alkyl, heteroaryl, heterocyclyl, halo-alkyl, hydroxy-alkyl, cycloalkyl-alkyl, and aralkyl; R5a is selected from the group consisting of hydrogen, alkyl, cycloalkyl-alkyl, and cyano; a stereoisomer, enantiomer, or tautomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, or a pro-drug thereof. |
| priorityDate | 2006-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 57.