| abstract |
A thienopyrimidine of formula (1) and its pharmaceutically acceptable salts have activity as PI3K inhibitors with selectivity for the P110alpha subtype, and can be used to treat diseases and disorders that arise from abnormal cell growth, function or behavior, in particular those associated with PI3 kinase, such as cancer, immune disorders, cardiovascular diseases, viral infections, inflammation, metabolic / endocrine disorders and neurological disorders. Processes to synthesize the compounds are also discovered. Claim 1: A compound that is a thienopyrimidine of formula (1) or a pharmaceutically acceptable salt thereof. |