| abstract |
Use of a compound of formula (1), wherein: R 1 is phenyl optionally substituted with halogen, cyano, C 1-4 alkyl or C 1-4 haloalkyl; R2 is hydrogen, C1-6 alkyl or C3-6 cycloalkyl; and R3 is a group that has an NH or an OH that has a calculated or measured pKa of between 1.0 and 8.0; or a salt acceptable to your pharmacist thereof; in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. It also refers to the benzenesulfonate salt of N- {3- [4- (3,4-dichlorophenoxy) piperidin-1-iI] -2-hydroxypropyl} -2,3-dihydro-2-oxo-4- (trifluoromethyl ) -5-thiazolcarboxamide, a process to do it, and its use in therapy (for example to treat a disease state mediated by CCR3s). Claim 16: A method of treating a disease state mediated by CCR3 characterized in that it comprises administering to a patient a therapeutically effective amount of a compound as claimed in claim 10 or 11. |