http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-060173-A1
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
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| filingDate | 2007-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571a56049700f9445fe2bc753adf02d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c353688bb10f62045de7fdb3c5617745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_804385a35cc1021dab010d30045c9954 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_037e59f9554c70ff97c56559eee6d3ba |
| publicationDate | 2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-060173-A1 |
| titleOfInvention | DERIVATIVES OF PYRIDINE AND PYRIMIDINE AS ANTAGONISTS OF MGLUR2, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF SNC DISORDERS. |
| abstract | Compounds of the formula (1), to a process for obtaining it, to its use for the manufacture of drugs intended for the treatment of CNS disorders and to pharmaceutical compositions containing them. Claim 1: A compound of the formula (1) in which: either one of X or Y is N and the other is CH, or X and Y are both N; A is 5 or 6 link aryl or heteroaryl, each of which is optionally substituted by C1-6 alkyl; B is H, cyano or, is an optionally substituted aryl or an optionally substituted 5 or 6-link heteroaryl, the substituents are chosen from the group consisting of: halogen; nitro; C1-6 alkyl optionally substituted by hydroxy, NRaRb, wherein Ra and Rb are independently H, C1-6 alkyl or - (CO) -C1-6 alkyl; -S-C 1-6 alkyl; - (SO2) -OH; - (SO2) -C1-6 alkyl; - (SO2) -NRcRd, in which Rc and Rd are independently: H, C1-6 alkyl optionally substituted by hydroxy, C1-6 haloalkyl, C1-6 alkoxy, - (CO) -C1-6 alkyl optionally substituted by C1-6 alkoxy, - (CH2CH2O) nCHRe, in which Re is H or CH2OH and n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, - (CH2) m-aryl, in which m is 1 or 2 and the aryl is optionally substituted by halogen or C1-6 alkoxy, - (CH2) p3-6 cycloalkyl, wherein p is 0 or 1, 5 or 6 link heterocycloalkyl; - (SO2) -NRfRg, in which Rf and Rg together with the nitrogen atom to which they are attached form a heterocycloalkyl ring of 4, 5 or 6 links that may optionally contain another heteroatom chosen from nitrogen, oxygen, sulfur and a group SO2, said 4, 5 or 6-link heterocycloalkyl ring is optionally substituted by: a substituent selected from the group consisting of hydroxy, C1-6 alkyl, C1-6 alkoxy which is optionally substituted by hydroxy and 5 or 6-link heteroaryloxy; NHSO2-C1-6 alkyl; NHSO2-NRhRi in which Rh and Ri are independently H, C1-6 alkyl, - (CO) O-C1-6 alkyl, or Rh and Ri together with the nitrogen atom to which they are attached form a heterocycloalkyl ring of 4 , 5 or 6 links which may optionally contain another heteroatom chosen from nitrogen, oxygen and sulfur, said 4, 5 or 6-link heterocycloalkyl ring is optionally substituted by C1-6 alkyl; R1 is H, halogen, C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy, C1-6 haloalkyl, C3-6 cycloalkyl; R2 is H, cyano, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkyl or C3-6 cycloalkyl; R3 is halogen, H, C1-6 alkoxy, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkoxy, or is NRjRk in which Rj and Rk are independently selected from the group consisting of: H, C3-8 cycloalkyl, aryl, heteroaryl having 5 to 12 ring atoms and C1-6 alkyl which is optionally substituted by one or more substituents chosen from the group consisting of halogen, hydroxy, C3-8 cycloalkyl, aryl , heteroaryl having 5 to 12 ring atoms and -NRlRm, in which Rl and Rm are independently selected from the group consisting of H and C1-6 alkyl; or Rj and Rk together with the nitrogen atom to which they are attached can form an optionally substituted heterocyclic group, which has 5 to 12 ring atoms and may optionally contain another heteroatom chosen from nitrogen, oxygen and sulfur, said heteroaryl group is optionally substituted by one, two, three, four or five substituents chosen from the group consisting of halogen, hydroxy, C1-6 alkyl and C1-6 haloalkyl; or R2 and R3 can together form a diox bridge; R4 is H or halogen; as well as its pharmaceutically acceptable salts. |
| priorityDate | 2006-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.