http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-059609-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_767d0d7a00b5d921c9324ee92aa9f0ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| filingDate | 2007-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e872ffb16a7eeb894cefd8f7e6fcd1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0d10887df2f99ab6083d7c45bc67bf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c53d3042e52736a404ac396b86491d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c07bafe0345f52f5b6613fdc6eab090 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f4fb4e7bf69f8f4048eb00737d54a6c |
| publicationDate | 2008-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-059609-A1 |
| titleOfInvention | INDOLOPIRIDINS |
| abstract | They are effective compounds with anti-proliferative and / or apoptosis inducing activity. Compounds, pharmaceutical composition, combinations, use and methods to treat are claimed. Claim 1: Compounds characterized in that they are of formula (1) wherein R 1 is C 1-4 alkyl, C 3-7 cycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-7 cycloalkyl-C 1-4 alkyl, or C 2- alkyl 7 substituted by R11, where R11l is -N (R111) R112, or halogen, where R111 is hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-7 cycloalkyl, C3-7- cycloalkyl C1-4 alkyl, hydroxy-C2-4-alkyl, C1-4 alkoxy-C2-4 alkyl, 1N (C1-4 alkyl) pyrazoyl, 1N- (H) -pyrazolyl, isoxazolyl, or C1-4 alkyl completely or partially substituted by fluoro, R112 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, or C3-7 cycloalkyl-C1-4 alkyl, or R111 and R112 together and with the inclusion of the nitrogen atom to which they are attached, they form a ring Het, where Het is piperidin-1-yl, morpholin-4- yl, thiomorpholin-4-yl, S-oxo-thiomorpholin-4-yl, S, S-dioxo-thiomorpholin-4-yl, pyrrolidin-1- ilo, azetidin-1-yl, homopiperidin-1-yl, 4N- (R113) -piperazin-1-yl, 4N- (R113) -homopiperazin-1-yl, 2,5-dih idro-pyrrol-1-yl, 1,2,3,6-tetrahydropyridin-1-yl, pyrrol-1-yl, pyrazol-1-yl, imidazol-1-yl, triazol-1-yl, or tetrazol-1-yl , wherein R113 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, C1-4 alkylcarbonyl, amidino, or C1-4 alkyl completely or partially substituted by fluoro, wherein said Het it may be optionally substituted by one or two substituents independently selected from fluoro and C1-4 alkyl; R2 is hydrogen, C1-4 alkyl, halogen, trifluoromethyl, C1-4 alkoxy, or hydroxyl, R3 is hydrogen, C1-4 alkyl, halogen, trifluoromethyl or C1-4 alkoxy, R4 is C1-4 alkyl, C3-7 cycloalkyl , or C3-7 cycloalkyl-C1-4 alkyl; R5 is C1-4 alkyl, halogen, C1-4 alkoxy, trifluoromethyl, cyano, hydroxy, phenyl C1-4 alkoxy, C1-4 alkoxy-C2-4 alkoxy, C2-4 alkoxy hydroxy, C3-7 cycloalkoxy, cycloalkyl C3-7-C1-4 alkoxy, or C1-4 alkoxy completely or predominantly substituted by fluoro, R6 is hydrogen, C1-4 alkyl or halogen, and the salts, stereoisomers and salts of the stereoisomers of these compounds. |
| priorityDate | 2006-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 40.