http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-059137-A1
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| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42dcb8afd289e295b65f450020cbfdb4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| filingDate | 2007-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-059137-A1 |
| titleOfInvention | COMPOUNDS DERIVED FROM INDOL AND PHARMACEUTICAL COMPOSITION |
| abstract | These compounds are useful in the treatment of hepatitis C. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein: X is: -cyano; -nitro; -formyl; -COOH; -CORx, where Rx is C1-6 alkyl, -CH = N- (C1-6 alkoxy); -CH = N- (amino optionally substituted with one or more C1-6 alkyl); -halo; -alkyl optionally substituted with one or more halo; -alkynyl optionally substituted with C1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo and / or cyano; -oximyl; -SO2Rx, -SO2NH2 -SO2NH (Rx); -SO2N (Rx) 2, -amino optionally substituted with one or more C1-6 alkyl and / or -C (O) -C1-6 alkyl, -amido optionally substituted with one or more independently selected C1-6 alkyl; - 5 or 6 member heterocycle; - 5 or 6-membered heteroaryl optionally substituted with one or more C1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; or -C6-8 aryl optionally substituted with one or more substituents independently selected from: -C1-6 alkyl optionally substituted with one or more halo; -halo; and -ciano; Y is: -benzothiazolyl optionally substituted with amino, wherein said amino is optionally substituted with one or more C1-6 alkyl, -indolyl optionally substituted in the nitrogen with -SO2Rx; -C6-8 aryl optionally substituted with one or more substituents independently selected from: -halo; -C 1-6 alkyl, -alkoxy optionally substituted with one or more substituents independently selected from: -one or more halo; and - 5 or 6 member heterocycle; -hydroxy; -amino optionally substituted with one or more substituents independently selected from: -SO2Rx, -C1-8 alkyl optionally and independently substituted with one or more 5- or 6-membered heteroaryl; and -PO2Rx; -OC (O) NHRx, -OC (O) N (Rx) 2 -OC (O) NH (ORx); -OC (O) NRx (ORx); -OC (O) N (Orx) 2, -OC (O) Rab, where Rab is a 5- or 6-membered heterocycle; -NRoCORp, where Rp is: -C1-6 alkyl, -amino optionally substituted with one or more C1-6 alkyl, wherein said alkyl is optionally and independently substituted with one or more C6-8 aryl and / or alkoxy; or -a 5- or 6-membered heterocycle optionally substituted with one or more C1-6 alkyl and / or C6-8 aryl, and where Ro is: hydrogen; or -C 1-6 alkyl; -NRqCONRqRr, where Rq is hydrogen; and where Rr is: -C 1-6 alkyl optionally substituted with one or more substituents independently selected from: -halo; -hydroxy; - alkoxy; - 5 or 6 member heterocycle; -5 or 6-membered heteroaryl; and -C6-8 aryl optionally substituted with one or more halo; C2-6 alkenyl optionally substituted with one or more halo; -C 1-6 alkoxy, or -a 5- or 6-membered heterocycle; - SO2Raa, where Raa is: -a 5- or 6-membered heterocycle optionally substituted with hydroxy; -C 1-6 alkoxy or -C 1-6 alkyl, CORm, where Rm is: -amino optionally substituted with one or more C 1-6 alkyl, wherein C 1-6 alkyl are optionally substituted with a 5- or 6-membered heterocycle; or -a 3- to 7-membered heterocycle optionally substituted with C1-6 alkyl, wherein the alkyl is optionally substituted with dialkyl amino; -NRtCOORu, where Rt is hydrogen, and where Ru is: - C1-12 alkyl optionally substituted with one or more substituents independently selected from: -C6-8 aryl optionally substituted with one or more halo and / or haloalkyl; -alkoxy optionally substituted with one or more alkoxy; -amino optionally substituted with one or more C1-6 alkyl, -halo; -5 or 6-membered heteroaryl; and - 5 or 6 member heterocycle; -C2-6 alkenyl or -C6-8 aryl optionally substituted with halo; -NHRbb, where Rbb is: -C (= S) NH2, or -PO (ORx) 2, -NRvSO2Rw, where Rv is hydrogen, and where Rw is: -C1-6 alkyl; or -alkyl- or dialkyl-amino optionally substituted with halo; formula (2) or (3); Z is: -C 1-6 alkyl optionally substituted with 5 or 6 membered heterocycle; or - 5 or 6 member heterocycle; R is H, R1 is: -hydrogen; - 5 or 6 member heterocycle; -C 1-6 alkyl optionally substituted with one or more substituents independently selected from: -amino optionally substituted with heterocycle; -amido optionally substituted with C1-6 alkyl, -5 or 6-membered heterocycle optionally substituted with C1-6 alkyl, -5 or 6-membered heteroaryl; and -C6-8 aryl, -C 1-6 alkoxy optionally substituted with one or more substituents independently selected from: -amino optionally substituted with heterocycle; -amido optionally substituted with C1-6 alkyl, -5 or 6-membered heterocycle optionally substituted with C1-6 alkyl, -5 or 6-membered heteroaryl; and -C6-8 aryl, - (O) -5 or 6-membered heterocycle; - (O) -5 or 6-membered heteroaryl; -SO2Rx optionally substituted with one or more substituents independently selected from: -5 or 6-membered heterocycle; C6-8 aryl and 5 or 6 membered heteroaryl; or -alkylthio optionally substituted with one or more substituents independently selected from: -5 or 6-membered heterocycle; C6-8 aryl and 5 or 6 membered heteroaryl; R2 is: -C 1-6 alkyl optionally substituted with one or more substituents independently selected from: -5 or 6-membered heterocycle; -5 or 6-membered heteroaryl; -C6-8 aryl, -amido optionally substituted with C1-6 alkyl and -amino optionally substituted with one or more substituents independently selected from: heterocycle, alkoxy and alkyl, where the alkyl is optionally substituted with one or more alkoxy; - alkylthio optionally substituted with 5 or 6 membered heteroaryl, wherein said heteroaryl is optionally substituted with alkyl; -alkylthio optionally substituted with a 5- or 6-membered heterocycle; -alkylthio optionally substituted with C6-8 aryl, -alkylthio optionally substituted with C1-6 alkyl, -SO2Rx optionally substituted with a 5- or 6-membered heteroaryl, wherein said heteroaryl is optionally substituted with one or more C1-6 alkyl; -SO2Rx optionally substituted with a 5- or 6-membered heterocycle; -SO2Rx optionally substituted with C6-8 aryl, -SO2Rx optionally substituted with C1-6 alkyl, -S (O) Rx optionally substituted with a 5 or 6 membered heteroaryl; -S (O) Rx optionally substituted with a 5- or 6-membered heterocycle; -S (O) Rx optionally substituted with C6-8 aryl, -S (O) Rx optionally substituted with C1-6 alkyl, -alkoxy optionally substituted with one or more substituents independently selected from: -halo; -hydroxy; -alkoxy optionally substituted with alkoxy; -amino optionally substituted with one or more substituents independently selected from 5 or 6 membered heteroaryl, 5 or 6 membered heterocycle and alkyl, wherein the alkyl is optionally substituted with one or more substituents independently selected from: - 5 or 6 membered heterocycle ; and -amino optionally substituted with one or more alkyl; -amido optionally substituted with C1-6 alkyl, -S-5- or 6-membered heterocycle; -S-5- or 6-membered heteroaryl optionally substituted with C1-6 alkyl, -S-C1-6 alkyl, -S-C6-8 aryl, -sulfinyl-5- or 6-membered heterocycle; - 5 or 6 membered sulfinyl heteroaryl; -sulfinyl-C1-6 alkyl, -sulfinyl-C6-8 aryl, -sulfonyl-5- or 6-membered heterocycle; 5 or 6-membered sulfonyl-heteroaryl optionally substituted with C1-6 alkyl, -sulfonyl-C1-6 alkyl, -sulfonyl-C6-8 aryl, -5 to 7-membered heterocycle optionally substituted with one or more substituents independently selected from hydroxy and C1-6 alkyl, wherein the alkyl is optionally substituted with one or more C1-6 alkoxy, 5- or 6-membered heteroaryl optionally substituted with one or more C1-6 alkyl and -C6-8 aryl, -C6 -aryl 8, - (O) -5 or 6-membered heteroaryl optionally substituted with one or more independently selected C1-6 alkyl; -C (O) -5 or 6-membered heterocycle optionally substituted with one or more C6-8 aryl, -C (O) -C6-8 aryl, -COOH; -C (O) NH2 optionally substituted with one or more substituents independently selected from: -C1-6 alkyl optionally substituted with one or more substituents independently selected from halo, C1-6 alkoxy, hydroxy, 5- or 6-membered heterocycle and heteroaryl of 5 or 6 members; -amido optionally substituted with one or more C1-6 alkyl, wherein the alkyl is optionally substituted with one or more C1-6 alkoxy, -5 or 6-membered heteroaryl optionally substituted with one or more substituents independently selected from -C1-6 alkyl and -5 or 6-membered heterocycle optionally substituted with one or more substituents independently selected from: -hydroxy; -C1-6 alkyl, -SO2Rx, -C (O) -C6-8 aryl, and -C (O) Orx, or -ORkk, where Rkk is: -C6-8 aryl, 5- or 6-membered heterocycle substituted optionally with C1-6 alkyl, wherein said alkyl is optionally substituted with C6-8 aryl, 5- or 6-membered heteroaryl optionally substituted with one or more substituents independently selected from halo, C1-6 alkyl, C1-6 alkoxy, and haloalkyl C1-6, -SO2Rx, or -Si (Rx) 3 and R3 is hydrogen; with the proviso that at least one of X, Y, Z, R1, and R2 is selected from the following: X is: -COOH, -CH = N- (C1-6 alkoxy); -CH = N- (amino optionally substituted with one or more C1-6 alkyl; -halo; -alkyl optionally substituted with one or more halo; alkynyl optionally substituted with C1-6 alkyl, where the alkyl is optionally substituted with one or more halo and / or cyano; -oximyl; -SO2Rx, -SO2NH2, -SO2NH (Rx), -SO2N (Rx) 2, -amino optionally substituted with one or more C1-6 alkyl and / or -C (O) C1 alkyl -6, -amido optionally substituted with one or more independently selected C1-6 alkyl; -5 or 6-membered heterocycle; -5 or 6-membered heteroaryl substituted with one or more C1-6 alkyl, where the alkyl are substituted with one or more halo; or -C6-8 aryl substituted with one or more substituents independently selected from: - |
| priorityDate | 2006-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 20.