http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-059114-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| filingDate | 2006-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31bc511dea5737e363941b56904370a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e35f8e044291a2a0d64a26429c153440 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fde41eba78e958abd4c83d1618ed9c77 |
| publicationDate | 2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-059114-A1 |
| titleOfInvention | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS |
| abstract | Claim 1: A method for preparing a compound of the formula (1) characterized in that R1 is C1-6 alkyl or C3-6 cycloalkyl; Each R2a, R2b and R2c is independently selected from: hydrogen, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, -OR12a, -CF3, -CN and -NR1aR12b, R4 is selected from: hydrogen, C1-6 alkyl, - (CR9R10) nR11, -CF3, halogen OR12a, -CN and -NR12aR12b: R5 is selected from hydrogen, C1-6 alkyl, - (CR6R10) nR11, -CF3, halogen OR12a, -CN and NR12aR12b; R6 is selected from: hydrogen, C1-6 alkyl, - (CR9R10) nR11, -CF3, halogen, -OR12a, -CN and NR12aR12; R7 is selected from hydrogen, C1-C6 alkyl, - (CR9R10) nR11, -CF3, halogen, OR12a, -CN and NR12aR12b; Each R9 and R10 is independently selected from hydrogen and C1-6 alkyl or R9 and R10, together with the carbon atom to which they are attached, form a C3-C6 cycloalkyl group; Each R11 is independently selected from: hydrogen, C1-6 alkyl, halogen, -OR12a, -CN, -CF3 and NR9R10, each R12a and R12b is independently selected from hydrogen and C1-C6 alkyl and each n is independently selected and is a integer from 0 to 5; said method comprising: a) treating a compound of the formula (V), in which R1 was defined above, with an anion of a compound of the formula (X), in which R13 is: hydrogen, C1-6 alkyl, -If (C1-6 alkyl) 3 or CH2 (C6-10 aryl in which said C6-10 aryl group is optionally substituted with at least one substituent selected from: halogen, C1-6 alkyl, -OH, -OCH3 and N (C1-6 alkyl) 2, to provide a compound of formula (IV); b) hydrolyze the compound of formula (IV) to provide a compound of formula (IV) in which R13 is hydrogen; c) treating the compound of the formula (IV) with a combination of reagents to provide a compound of the formula (III) in which P1 is hydrogen or a suitable protecting group and R14 is: C1-6 alkyl or CH2 (C6 aryl -10) wherein said C6-10 aryl group is optionally substituted with at least one substituent selected from: halogen, C1-6 alkyl, -OH, -OCH3 and -N (C1-6 alkyl) 2; d) treating the compound of formula (III) with an acid or a base to provide a compound of formula (II) and e) treating the compound of formula (II) with a compound of formula (IXa), to provide the compound of the formula (Ia). |
| priorityDate | 2005-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.