http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-059064-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| filingDate | 2007-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86fda359f5446bd4e4b557fbfece82d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90c0d95ece6ec9cc383ed86e9326a60f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd4e68499685b22bf5332af8d37bd30e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a7c44cc73e87292a52c7c087458a2d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4a92f5e5f6b845c7c0b8ccb7fceba43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_955d7dd441f27cb85d0d2acb5f31163d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3a4bb299b82d4511208debdd5fef94b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd4f36694762c781e20348b0aab1c46e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87a220331e2c7de300f81cdc51336bdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9282589b35b0ddb01587507777bb0402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fce32fed7577b0472b9ef185aeb7cb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7488f918bafc782bdd326bf789ed7e2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8688bbaad5a181b86e0e5c9995358b26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d6a980826d815f3a90109fa20c5dae6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63062e553083752123d0970b19967128 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9687a13326c2e1860c5595fc39dc9cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2e1a273ae0592e218e8156e2583f5e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90cd152ea8609c6c7e04ba77a7405938 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fac87e80720b640db1018afff98475df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5034c0fd82fc7535c592c066afa5f15b |
| publicationDate | 2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-059064-A1 |
| titleOfInvention | TIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES IN THE TREATMENT OF DISEASES MEDIATED BY PROTEIN KINASE B (PKB), SUCH AS CANCER. |
| abstract | Claim 1: A compound of the formula (1) wherein: A is as shown in the formula (2) or aryl; Y is -N (R5) R6 or -OR6; X is O, S, or -N (R7); R1 is R8, -CHR11-N (H) -R8, -CHR11-O-R8, C2-6 alkynyl, C2-6 hydroxyalkynyl or -C ::: N; R2 is aryl or heteroaryl; R3 is -H, C1-6 alkyl, which may be interrupted by one or more heteroatoms, - (CR9R10) t (aryl), - (CR9R 10) t (heteroaryl), - (CR9R10) t (cycloalkyl) or - ( CR9R10) t (heterocyclyl); R4 is C1-6 alkyl, which may be interrupted by one or more heteroatoms, - (CR9R10) t (aryl), - (CR9R 10) t (heteroaryl), - (CR9R10) t (cycloalkyl) or - (CR9R10) t (heterocyclyl); or R3 and R4, together with the carbon atom to which both are bonded, join to form a C3-10 carbocyclic or heterocyclic ring system, or R4 and R7 join to form a C3-10 heterocyclic ring; R5 is -H, C1-8 alkyl, -C (O) (CR9R10) t) N (R7) 2, -C (O) (CR9R10) t -C (O) 2 (CR9R10) t, - (CR9R10) t (aryl), - (CR9R10) t (heteroaryl), - (CR9R10) t (cycloalkyl) or - (CR9R10) t (heterocyclyl), or R4 and R5 join to form a C3-10 heterocyclic ring; R6 and R7 are independently selected from -H, C1-8 alkyl, - (C1-6 alkyl) aryl, or -C (O) (C1-6 alkyl), or R6 and R7, together with the atoms to which they are linked, join to form a 5- to 6-membered heterocyclic ring, or R5 and R6, together with the nitrogen atom to which they are linked, join to form a 5- to 6-membered heterocyclic or heteroaryl ring; R8 is -H, C1-6 alkyl, - (C1-6 alkyl) aryl, aryl or heteroaryl; and R9, R10 and R11 are independently selected from -H, C1-6 alkyl or aryl; where n is an integer from 1 to 6; m is an integer from 0 to 2; and each t is, independently, an integer from 0 to 3; wherein each of the aforementioned alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl fractions, and heterocyclic and carbocyclic rings are optionally and independently substituted by 1 to 3 substituents which are selected from: amino, aryl, heteroaryl, cycloalkyl or heterocyclyl optionally substituted by 1 to 5 substituents selected from C1-6 alkoxy, C1-6 alkyl optionally substituted by halo, aryl, halo, hydroxyl, heteroaryl, C1-6 hydroxyalkyl, or -NHS (O) 2- (C1-6 alkyl); C 1-6 alkyl, C 2-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 1-6 alkyl, amino, C 2-6 alkenyl or C 2-6 alkynyl, where each of which may be interrupted by one or more heteroatoms, cyano, halo, hydroxyl, nitro, or -O-aryl; or a pharmaceutically acceptable salt, hydrate or stereoisomer thereof. |
| priorityDate | 2006-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.