http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-058587-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| filingDate | 2006-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-058587-A1 |
| titleOfInvention | PIRROLO-1,5-NAFTIRIDINONE COMPOUNDS, ITS USE AS ANTIBACTERIAL AGENTS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND INTERMEDIARY COMPOUNDS TO PREPARE SUCH COMPOUNDS |
| abstract | Pyrrolo-1,5-naphthyridone compounds of formula (1) or a pharmaceutically acceptable salt, solvate and / or N-oxide thereof: wherein R1a and R1b are independently selected from hydrogen; halogen; cyano, (C1-6) alkyl; alkylthio (C1-6); trifluoromethyl; trifluoromethoxy; carboxy, hydroxy optionally substituted with (C1-6) alkyl or (C1-6) alkoxy-(C1-6) alkyl-substituted; (C1-6) alkoxy-(C1-6) alkyl-substituted; hydroxy (C1-6) alkyl; an amino group optionally N-substituted with one or two (C1-6) alkyl, formyl, (C1-6) alkylcarbonyl or (C1-6) alkyl sulfonyl groups; or aminocarbonyl in which the amino group is optionally substituted with (C1-4) alkyl; R2 is hydrogen, or (C1-4) alkyl, or together with R6 form Y as defined below; A is a group (ia) or (ib): in which: R3 is as defined for R1a or R1b or is oxo and n is 1 or 2: or A is a group (ii) W1, W2 and W3 are CR4R8 or W2 and W3 are CR4R8 and W1 represents a link between W3 and N, X is O, CR4R8, or NR6, n R4 is as defined for R1a and R1b and the rest and R8 are hydrogen, or a R4 and R8 together are oxo and the rest are hydrogen, R6 is hydrogen or (C1-6) alkyl; or together with R2 is hydrogen; halogen; hydroxy optionally substituted with (C1-6) alkyl or (C1-6) alkyl; Y is CR4R8CH2; CH2CR4R8; (C = O); CR4R8; CR4R8 (C = O); or (C = O) CR4R8; or when X is CR4R8, R8 and R7 together represent a link; U is selected from CO and CH2, and R5 is an optionally substituted carbocyclic or heterocyclic (B) bicyclic ring system: containing up to four heteroatoms in each ring, in which at least one of the rings (a) and (b) it is aromatic; X1 is C or N when it is part of an aromatic ring, or CR14 when it is part of a non-aromatic ring; X2 is N, NR13, O, S (O) x, CO or CR14 when it is part of an aromatic or non-aromatic ring, or it can also be CR14R15 when it is part of a non-aromatic ring; X3 and X5 are independently N or C; Y1 is a connecting group of 0 to 4 atoms, each of whose atoms is independently selected from N, NR13, O, S (O) x, CO and CR14 when it is part of an aromatic or non-aromatic ring, or it can be additionally CR14R15 when it is part of a non-aromatic ring; Y2 is a connecting group of 2 to 6 atoms, and each atom of Y2 is independently selected from N, NR13, O, S (O) x, CO, CR14 when it is part of an aromatic or non-aromatic ring, or it can be additionally CR14R15 when it is part of an aromatic ring; Y2 is a connecting group of 2 to 6 atoms, and each atom of Y2 is independently selected from N, NR13, O, S (O) x, CO, CR14 when it is part of an aromatic or non-aromatic ring, or it can be additionally CR14R15 when part of a non-arimatic ring; each of R14 and R15 is independently selected from: H; alkylthio (C1-4); halogen; carboxy-C1-4 alkyl; (C1-4) alkyl; (C1-4) alkoxycarbonyl; (C1-4) alkylcarbonyl; (C1-4) alkoxy-(C1-4) alkyl; hydroxy; hydroxy (C1-4) alkyl; (C1-4) alkoxy; nitro; cyano; carboxy; amino or aminocarbonyl optionally mono or disubstituted with (C1-4) alkyl; or R14 and R15 together may represent oxo; each R13 is independently H; trifluoromethyl; (C1-4) alkyl optionally substituted with hydroxy, (C1-6) alkoxy, (C1-6) alkylthio, halogen or trifluoromethyl; (C2-4) alkenyl, (C1-4) alkoxycarbonyl; (C1-4) alkylcarbonyl; (C1-6) alkyl sulfonyl; aminocarbonyl in which the amino group is optionally mono or disubstituted with (C1-4) alkyl; each x is independently 0, 1 or 2; and R9 is fluoro or hydroxy. Use of said compounds for the manufacture of a medicament for the treatment of bacterial infections and pharmaceutical compositions comprising them. Intermediate compounds for the preparation of the compound of formula (1). |
| priorityDate | 2005-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 23.