http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-057880-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803 |
| filingDate | 2006-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-057880-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF AMIDAS AND ESTERES PIRIDILCARBOXILICOS |
| abstract | Claim 1: A process for the preparation of pyridylcarboxylic amides and esters (1), wherein Hal represents a halogen atom; X represents O or NR2; R1 represents a C1-6 alkyl or aryl group, in which both groups can be substituted by one or more halogen atoms, nitro, cyano, C1-6 alkyl, halo- C1-6 alkyl or C1-6 alkoxy groups. ; R2 represents a hydrogen atom or a C1-6 alkyl group; characterized in that it comprises the following steps: A) heating a mixture consisting essentially of tricoloromethylpyridine (2), in which Hal has the indicated meaning, and 1.0 to 1.5 equivalent of concentrated sulfuric acid, characterized in that the trichloromethylpyridine 2 in form liquid is added to the concentrated sulfuric acid at a temperature of 110 to 160 ° C; and b) reacting the intermediate product obtained in step (a) with an amine or alcohol HXR1, in which X and R1 have the indicated meaning, optionally in the presence of a solvent and / or a base. Claim 12: A process for the preparation of amides and (aryloxy) pyridylcarboxylic esters (4), in which Y represents O or NR2; R1 represents a C1-6 alkyl or aryl group, in which both may be substituted by one or more halogen atoms, nitro, cyano, C1-6 alkyl, halo- C1-6 alkyl or C1-6 alkoxy groups; R2 represents a hydrogen atom or a C1-6 alkyl group; R 3 represents an aryl group, which may be substituted by one or more halogen atoms, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy or C 1-6 haloalkyl groups; characterized in that it comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine 2, as defined above, and 1.0 to 1.5 equivalent of concentrated sulfuric acid, characterized in that trichloromethylpyridine 2 is added in liquid form to the concentrated sulfuric acid, at a temperature of 110 to 160 ° C; (b) reacting the intermediate product obtained in step (a) with an amine or an HXR1 alcohol, as defined above, optionally in the presence of a solvent and / or a base; and (c) reacting the pyridylcarboxylic amides and esters 1 or a salt thereof, obtained in step (b), with an aromatic alcohol R3-OH, in which R3 has the indicated meaning; optionally in the presence of a base. |
| priorityDate | 2005-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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