http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-057650-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| filingDate | 2006-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7763d9a4f7015383344c3a9cbbe6be0 |
| publicationDate | 2007-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-057650-A1 |
| titleOfInvention | PROCESS FOR THE ALKIN HYDROBORATION GUIDED BY ZR |
| abstract | A process for Zr-mediated hydroboration of alkynes that offer high-performance (E) -vinylboronic esters with stereoselectivity and regioselectivity. It comprises reacting a substituted terminal alkyne of the formula (1), with a compound of the formula (2), in the presence of bis (cyclopentadienyl) zirconium chloride hydride and triethylamine at about 60sC, to obtain a compound of the formula (3 ), wherein: X is a divalent group comprising an alkyl, an aryl or a heteroaryl; R1 is an alkyl, wherein R1 groups may optionally form a 5-12 membered monocyclic or bicyclic ring; Y is an H, an alkyl, an alkenyl, an aryl, a heteroaryl, halogen, CN, NH2, CO2H, N3, CHO, CF3, OCF3, OR2, OSi (R2) 3, S (O) mR2, OS (O ) mR2, Q, OR3Q, NR2S (O) mR2, OR3OR2, where R3 and R2 together can optionally form a heterocyclic ring, OR2Q, N (R2) R3OR2, N (R2) R3Q, NR2C (O) R2, C ( O) R2, C (O) OR2, C (O) Q, OC (O) R2, OC (O) Q, NR2C (O) R2, NR2C (O) OR2, NR2C (O) Q; m = 0-2; R2 is an H, an alkyl, an alkenyl or an aryl optionally substituted by an alkyl; R3 is a divalent alkyl or an alkenyl; Q is NZZ 'or N (O) ZZ'; Z and Z 'are the same or different groups comprising, an H, an alkyl, an alkenyl, an aryl or a heteroaryl, wherein Z and Z' taken together with the nitrogen to which they are attached can form a heterocyclic ring. Claim 1: A process for a hydrochlorination of alkyls guided by Zr-, characterized by: reacting a substituted terminal alkyne of the formula (1) with a compound of the formula (2), without a solvent or in an inert solvent in the presence of chloride (cyclopentadienyl) zirconium hydride and an amine at temperatures of about 20-150sC, to obtain a compound of the formula (3), wherein: X is a divalent group comprising an alkyl, an aryl or a heteroaryl ; R1 is an alkyl, wherein R1 groups may optionally form a 5-12 membered monocyclic or bicyclic ring; Y is an H, an alkyl, an alkenyl, an aryl, a heteroaryl, halogen, CN, NH2, CO2H, N3, CHO, CF3, OCF3, OR2, OSi (R2) 3, S (O) mR2, OS (O ) mR2, Q, OR3Q, NR2S (O) mR2, OR3OR2, where R3 and R2 together can optionally form a heterocyclic ring, OR2Q, N (R2) R3OR2, N (R2) R3Q, NR2C (O) R2, C ( O) R2, C (O) OR2, C (O) Q, OC (O) R2, OC (O) Q, NR2C (O) R2, NR2C (O) OR2, NR2C (O) Q; m = 0-2; R2 is an H, an alkyl, an alkenyl or an aryl optionally substituted by an alkyl; R3 is a divalent alkyl or an alkenyl; Q is NZZ 'or N (O) ZZ'; Z and Z 'can be the same or different groups comprising, an H, an alkyl, an alkenyl, an aryl or a heteroaryl, where Z and Z' taken together with the nitrogen to which they are attached can form a heterocyclic ring . |
| priorityDate | 2005-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.