| abstract |
Nitrogenous chemical compounds obtained by molecular modeling in silico, and whose structure allows the blocking of phosphorylation by integrating said compounds with the phosphorylation domain or its surroundings in the substrates of the enzyme Casein Kinase 2. It also includes pharmaceutical compositions containing said compounds and their use in the preparation of medicaments for the treatment of diseases related to neoplastic processes. Claim 1: Chemical compounds which block phosphorylation by Casein Kinase 2 (CK2) and with antineoplastic action, characterized in that it meets one or more of the following requirements: a) they bind to the phosphorylation domain or its environment in the substrate of the CK2, directly or indirectly blocking the binding of the enzyme to the substrate; b) directly or indirectly prevent the transfer of the phosphate group to the phosphoceptor serine; c) its binding to the substrate protein of CK2, generates a conformational change in the phosphorylation domain, its surroundings both directly or indirectly, according to those described in a) and b). |