http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-056203-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| filingDate | 2006-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-056203-A1 |
| titleOfInvention | PHENYL DERIVATIVES- [1,2,4] -OXADIAZOL-5-ONA WITH PHENYLL GROUP, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL PRODUCT AND THE USE OF THIS IN THE PROFILAXIS OR TREATMENT OF SNC AND GLUCOSE METABOLISM AND OF THE FATTY ACIDS |
| abstract | Phenyl- [1,2,4] -oxadiazol-5-one derivatives with a phenyl group in all its stereoisomeric forms and mixtures in any relationship, and its physiologically acceptable salts and tautomeric forms showing PPARd agonist activity. The compounds are suitable for the treatment and / or prevention of fatty acid metabolism disorders and glucose utilization disorders as well as disorders in which insulin resistance and demyelination and other neurodegenerative disorders of the nervous systems are involved central and peripheral. Claim 1: Compounds of formula (1), wherein R1 is H, halogen, C1-8 alkyl, C0-4-O-alkylene C0-4-H, C3-7 cycloalkyl, SCH3, CN, C6 aryl 10, wherein alkyl, alkylene and aryl are not substituted or substituted 1 to 5 times with F; B is C (R4) or N; R2, R3 are independently H, halogen, C1-8 alkyl, C0-4-O-alkylene C0-4-H, C3-7 cycloalkyl, SCH3, CN, C6-10 aryl, wherein alkyl, alkylene and aryl they are not substituted or substituted 1 to 5 times with F; R2 and R3 together with the carbon atoms to which they are attached form a C6-10 aryl or C5-10 heteroaryl ring. R4 is H, halogen, C1-8 alkyl, C0-4-O-alkylene C0-4-H, C3-7 cycloalkyl, SCH3, CN, C6-10 aryl, in which alkyl, alkylene and aryl are not substituted or are substituted 1 to 5 times with F; X is O, S, S (O), S (O) 2, O-CH2, S-CH2, CH2-O, CH2-S; -CH2-; Z is a bond, C 1-8 alkylene, C 2-8 alkenylene, C 2-8 alkylidene, or C 1-6 alkylene-O-C 1-6 alkyl; one of U and V is N the other is S or O; W is a bond, C1-8 alkylene, C2-8 alkenylene, in which alkylene and alkenylene are not substituted or are mono-, di- or trisubstituted with OH and F; Y is a bond, O, S, S (O), S (O) 2, N (R6) and R5 is H, C1-8 alkyl, C0-4 alkylene-C3-13 cycloalkyl, C0-4-aryl alkylene C6-14, C2-8 alkenyl, C0-4 alkylene-C3-15 heterocycloalkyl, C0-4 alkylene-C3-15 heterocycloalkenyl, C0-4 alkylene-C5-15 heteroaryl, wherein alkyl and alkylene may be mono-, di- or trisubstituted with F, C1-4 alkyl and O-C0-4-H alkylene and in which cycloalkyl, aryl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are mono-, di- or trisubstituted with F, Cl, Br, CF3, C1-4 alkyl and C0-4-H-alkylene; R6 is H, C1-8 alkyl, C2-8 alkenyl, C0-4 alkylene C3-6 cycloalkyl, in which alkyl and alkenyl are not substituted or are mono-, di- or trisubstituted with F and O-C0-alkylene 4-H; R5 and R6 together with the nitrogen atom to which they are attached (Y = N (R6)) form a C3-9 heterocycloalkyl, C3-9 heterocycloalkenyl or C5-9 heteroaryl group which may additionally contain 1 to 3 N, O heteroatoms, S and which is unsubstituted or mono- or disubstituted with F, CF3, C1-4 alkyl, O-C1-4 alkyl, CH2-OH, SO2-C1-4 alkyl, CO-C1-4 alkyl, CO-NH2, NH-CO-C1-4 alkyl, C6-14 aryl and C5-15 heteroaryl; R7, R8 are independently selected from the group consisting of H, halogen, C1-8 alkyl, C0-4-O-alkylene C0-4-H, SCF3, SF5, S (O) 2CF3, C0-4-O alkylene -C6-12 aryl, C0-4 alkylene-C6-12 aryl, NO2, in which alkyl and alkylene are not substituted or are mono-, di- or trisubstituted with F and aryl is not substituted or is mono-, di- or trisubstituted with halogen, C1-4 alkyl or O-C1-4 alkyl; R9 is C1-4 alkyl, C2-6 alkenyl, C0-6 alkylene C6-14 alkylene, C0-6 alkylene C5-15 heteroaryl, C0-6 alkylene C3-8 cycloalkyl, C0-6 alkylene C3- cycloalkenyl 8, wherein alkyl and alkylene are not substituted or are mono-, di- or trisubstituted with F and aryl, heteroaryl, cycloalkyl and cycloalkenyl are not substituted or are mono-, di- or trisubstituted with halogen, C1-4 alkyl, -CF3, -CHF2, or O-C1-4 alkyl; R10 is H, F, C1-6 alkyl, C2-6 alkenyl, C0-6 alkylene-C6-14 alkylene, C0-6-heteroaryl C5-15 alkylene, C0-6-C3-8 cycloalkyl, C0-6 alkylene -C3-8cycloalkenyl, in which alkyl and alkylene are not substituted or are mono-, di- or trisubstituted with F and aryl, heteroaryl, cycloalkyl and cycloalkenyl are not substituted or are mono-, di- or trisubstituted with halogen, alkyl C1-4, -CF3, -CHF2, or O-C1-4 alkyl; in all its stereoisomeric forms, enantiomeric forms and mixtures in any relationship, and its pharmaceutically acceptable salts and tautomeric forms. |
| priorityDate | 2005-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 50.