http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-056044-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42a59c5faed1d0699d86edc5a2eee671 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| filingDate | 2006-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d7999abfb7c3d0bbd0ea3a71c6111b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071498bf4688f9ac731c3f23173f1774 |
| publicationDate | 2007-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-056044-A1 |
| titleOfInvention | TETRAHYDROCHINOLINONES AND ITS USE AS METABOTROPIC GLUTAMATE RECEPTORS MODULATORS |
| abstract | Claim 1: A compound characterized in that it is of the formula (1), wherein: R 1 represents aryl or heteroaryl; R2 and R3, which may be the same or different from each other, represent hydrogen or C1-6 alkyl; R4 and R5, which may be the same or different from each other, represent hydrogen or C1-6 alkyl; it being understood that: aryl represents a phenyl ring that is substituted with 1, 2, 3, 4 or 5 substituents, which may be the same or different from each other, which are selected from the group consisting of C1-6 alkyl, which is optionally substituted with one or more fluorine, chlorine or bromine atoms, C1-6 alkoxy, which is optionally substituted with one or more fluorine, chlorine or bromine atoms, C3-12 cycloalkyl, hydroxyl, F, Cl, Br, I, CN, nitro , di-C 1-6 alkylamino, N-cyclo-C 3-12 alkyl-N-C 1-6 alkylamino, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, 4-C 1-6 alkyl-piperazinyl, tetrazolyl, oxazolyl, furyl, pyrrolyl, thiophenyl, isoxazolyl, thiazolyl, thiazolyl, , imidazolyl, oxadiazolyl, pyridinyl, pyrimidyl and phenyl; heteroaryl represents a (hetero) aromatic of 5, 6 or 7 members with between 1 to 4 heteroatoms where said heteroatoms are independently selected from oxygen, nitrogen and sulfur, where said ring is not substituted or is substituted with 1, 2 or 3 substituents, which may be the same or different from each other, which are selected from the group consisting of C1-6 alkyl, which is optionally substituted with one or more fluorine, chlorine or bromine atoms, C1-6 alkoxy, which is optionally substituted with one or more fluorine, chlorine or bromine atoms, C3-12 cycloalkyl, hydroxyl, F, Cl, Br, I, CN, nitro, diC1-6 alkylamino, N-cycloC3-12 alkyl-N-C1-6 alkylamino , azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, 4-C1-6-piperazinyl, tetrazolyl, oxazolyl, furyl, pyrrolyl, thiophenyl, isoxazolyl, thiazolyl, imidazolyl, oxadiazolyl, pyridinyl, pyrimidyl and phenyl; and that the compounds of formula (1) cannot represent: 2-Phenylethynyl-7,8-dihydro-6H-quinolin-5-one; 2-Pyridin-3-iletinyl-7,8-dihydro-6H-quinolin-5-one; 2-m-Tolyletinyl-7,8-dihydro-6H-quinolin-5-one; 2- (3-Hydroxy-phenylethynyl) -7,8-dihydro-6H-quinolin-5-one; 2- (3-Methoxy-phenylethynyl) -7,8-dihydro-6H-quinolin-5-one; 2- (3-Fluoro-phenylethynyl) -7,8-dihydro-6H-quinolin-5-one; 2- (3-Chloro-phenylethynyl) -7,8-dihydro-6H-quinolin-5-one; 2- (3-Bromo-phenylethynyl) -7,8-dihydro-6H-quinolin-5-one; 3- (5-Oxo-5,6,7,8-tetrahydro-quinolin-2-iletinyl) -benzonitrile; 2-Thiazol-5-iletinyl-7,8-dihydro-6H-quinolin-5-one; 2-Oxazol-5-iletinyl-7,8-dihydro-6H-quinolin-5-one; 7,7-Dimethyl-2-pyridin-3-iletinyl-7,8-dihydro-6H-quinolin-5-one; 7,7-Dimethyl-2-m-tolyletinyl-7,8-dihydro-6H-quinolin-5-one; 2- (3- Hydroxy-phenylethynyl) -7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one; 2- (3-Methoxy-phenylethynyl) -7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one; 2- (3-Fluoro-phenylethynyl) -7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one; 2- (3-Chloro-phenylethynyl) -7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one; 2- (3-Bromo-phenylethynyl) -7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one; 3- (7,7-Dimethyl-5-oxo-5,6,7,8-tetrahydro-quinolin-2-iletinyl) -benzonitrile; 7,7-Dimethyl-2-thiazol-5-iletinyl-7,8-dihydro-6H-quinolin-5-one; 7,7-Dimethyl-2-oxazol-5- iletinyl-7,8-dihydro-6H-quinolin-5-one; 2- (2-Phenyl-oxazol-5-iletinyl) -7,8-dihydro-6H-quinolin-5-one; or 2- (2-Phenyl-thiazol-5-iletinyl) -7,8-dihydro-6H-quinolin-5-one; and optical isomers, salts acceptable for pharmaceutical use, hydrates, solvates and polymorphs thereof. |
| priorityDate | 2005-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.