| abstract |
An acid addition salt of (-) - (3R) -quinuclidin-3yl (1R) -1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate is provided with an acid selected from the group S formed by acid (-) - (2S, 3S) -tartaric acid (+) - (2S, 3S) -di-O-benzoyltartaric acid, (+) - (2S, 3S) -di-O- (4-methylbenzoyl) tartaric acid , (-) - L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+) - camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has low hygroscopicity that affects the use of a drug or its drug substance, and is very useful as a drug or its drug substance. The compound herein is useful as therapy in urological, respiratory and digestive tract diseases such as irritable bowel and spastic colitis. |