http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-055370-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 |
| filingDate | 2006-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f6977df5a366198752fcb938255a3f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209259f9f93ce12923b6dae8f91c4a70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf6c9f26a5b80865f5e8a8e16bf9da7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c19b6194e057f51dba0e04a8a93a1329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45590828fce09c7cdec31e2339d1a132 |
| publicationDate | 2007-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-055370-A1 |
| titleOfInvention | DERIVATIVES 2- OXO-AZEPAN REPLACED WITH FLUOR |
| abstract | Compounds with the general formula (1), in which: R1 is lower alkyl substituted by halogen, or is aryl or heteroaryl, not substituted or substituted by halogen; R2 is heterocycloalkyl, aryl or heteroaryl, which is not substituted or substituted by one or more substituents, selected from the group consisting of halogen, lower alkyloxy, lower alkyl substituted by halogen, O-lower alkyl substituted by halogen or is substituted by C (O) -NR''2, (CR2) mC (O) -R ', heteroaryl or S (O) 2-lower alkyl; R3 / R3 ', R4 / R4' and R5 / R5 'are independently of each other hydrogen or fluorine, in which at least one of R4 / R4' or R5 / R5 'is always fluorine; R 'is aryl or hydroxy; R '' is hydrogen, cycloalkyl or is heterocycloalkyl; R is hydrogen or lower alkyl; m is 0, 1, 2 or 3; and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. It has been found that the compounds with the general formula (1) are gamma-secretase inhibitors and related compounds may be useful in the treatment of Alzheimer's disease or common cancers, which includes but is not limited to cervical carcinomas. and breast carcinomas and hematopoietic system neoplasms. |
| priorityDate | 2005-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.