http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-054849-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 |
| filingDate | 2006-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-054849-A1 |
| titleOfInvention | DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM |
| abstract | It refers to methods for synthesizing useful compounds such as 5HT2c agonists or partial agonists, derivatives thereof, and intermediates to obtain them. Claim 1: A method of preparing a compound of formula (2) or a pharmaceutically acceptable salt thereof, wherein: n is 0, 1 or 2; R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, --C 1-6 perfluoroalkyl, or -O-C 1-6 perfluoroalkyl; each R is independently H or C1-6 alkyl; and R7 is H or C1-6 alkyl, which comprises the steps of: (a) providing a compound of formula E where R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C1 -perfluoroalkyl 6, or -O-C1-6 perfluoroalkyl; and each R is independently H or C1-6 alkyl; (b) treating said compound of formula E with a chiral agent to form a compound of formula D-1; where R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C 1-6 perfluoroalkyl, or -O-C 1-6 perfluoroalkyl; each R is independently H or C1-6 alkyl; and X is a chiral agent; (c) obtain a compound of formula D by suitable physical means; where R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C 1-6 perfluoroalkyl, or -O- C 1-6 perfluoroalkyl; each R is independently H or C1-6 alkyl; and X is a chiral agent; (d) treating said compound of formula D with a suitable base to provide a compound of formula C; where R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C 1-6 perfluoroalkyl, or -O-C 1-6 perfluoroalkyl; and each R is independently H or C1-6 alkyl; (e) renting said compound of formula C to form a compound of formula B, where n is 0, 1, or 2; R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C 1-6 perfluoroalkyl, or -O-C 1-6 perfluoroalkyl; each R is independently H or C1-6 alkyl; and PG2 is a suitable amino protecting group; (f) deprotecting said compound of formula B to form a compound of formula A, where n is 0, 1, or 2; R1 and R2 are each independently halogen, -CN, phenyl, -R, -OR, -C 1-6 perfluoroalkyl, or -O-C 1-6 perfluoroalkyl; and each R is independently H or C1-6 alkyl; and (g) reacting said compound of formula A with formaldehyde, or unequivalent thereof, to form a compound of formula (2). |
| priorityDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.