http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-054803-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-536 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 |
| filingDate | 2006-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66a6fc4b24bc915e3b31b4d62629bf68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fad6ddaae6f8bd2c0a3a413c69b80680 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52a496958f13e32b797715907d2fbb3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd20afaa85c8284db8c30cea00698a9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_120b1d5e16481ee585c743d95152cc06 |
| publicationDate | 2007-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-054803-A1 |
| titleOfInvention | USE OF NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
| abstract | Non-steroidal progesterone receptor modulators of the general formula (1), their use for preparing medicaments, as well as pharmaceutical compositions containing these compounds. The compounds are suitable for the therapy and prevention of gynecological diseases such as endometriosis, uterine leiomyomas, dysfunctional hemorrhages and dysmenorrhea, as well as for the therapy and prevention of hormone-dependent tumors and for use in the control of female fertility. and hormone replacement therapy. Claim 1: Use of non-steroidal compounds of the general formula 1 wherein R1 is an unsubstituted or possibly substituted aryl or heteroaryl group with up to 3 radicals, wherein the substituents have, independently of each other, the following meaning: C1-C5 alkyl, C2-5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, aryl, C1-C5 alkoxy, aryloxy, C1-C5 alkanoyl, aroyl, C1-C5 alkoxycarbonyl, C1-C5-oxy alkanoyl, aminocarbonyloxy, C1-C5-aminocarbonyloxy, C1-C5-alkylcarbonyloxy, aminocarbonyl, C1-C5-aminocarbonyl alkyl, C1-C5-aminocarbonylalkyl, C1-C5-amino alkanoyl, C1-C5-carbonylamino, C1-C5 alkyl sulfonylamino, C1-C5 alkyl-aminosulfonyl, dialkyl C1-C5 amino sulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, nitro, amino, with a mono or disubstituted nitrogen atom, wherein the substituents on the nitrogen are independently of each other , C1-C5 alkyl or aryl or ureido, where each nitrogen is substituted it, independently, with C1-C5 alkyl or C1-C5-thio alkyl, wherein the sulfur can be optionally oxidized in a sulfoxide or sulfone, or where each substituent, independently of each other, can be substituted for its Once with 1-3 radicals of the following meaning: methyl, halogen, hydroxy, oxo, cyano, trifluoromethyl and amino, R2 and R3 are in each case, independently of each other, hydrogen, C1-C5 alkyl, or R2 and R3 form along with the carbon atom of the chain a ring with a total of 3-8 carbon atoms R4 is Ch2 or C = O; R5 is a carbocyclic, heterocyclic, aromatic or heteroaromatic ring unsubstituted or optionally substituted with C1-C8 alkyl or C2-C8 alkenyl or a C1-C8 aryl-haloalkyl radical, wherein each substituent may in turn be independently substituted with each other, with 1-3 radicals with the following meaning: C1-C5, C2-C5 alkenyl, phenoxy, C1-C5 alkanoyl, aroyl, C1-C5 alkoxycarbonyl, C1-C5-oxy alkanoyl, aminocarbonyloxy, C1- alkyl C5-aminocarbonyloxy, C1-C5 dialkyl-aminocarbonyloxy, aminocarbonyl, C1-C5-aminocarbonyl alkyl, C1-C5-alkylcarbonyl, C1-C5-amino alkanoyl, C1-C5-carbonylamino, C1-C5-sulfonylamino alkyl, C1-alkyl -C5-aminosulfonyl, dialkyl C1-C5-aminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, nitro, amino, with a mono- or disubstituted nitrogen atom, where the substituents on the nitrogen are, independently of each other , C1-C5 alkyl or aryl or ureido, wherein each nitrogen is substituted, d and independently, with C1-C5 alkyl or C1-C5-thio alkyl, wherein the sulfur can be optionally oxidized in a sulfoxide or sulfone, and R6 is an unsubstituted aromatic compound or optionally substituted with 1-3 radicals or a group A or B: where each R6 substituent independently has the following meaning: C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, V3-C8 cycloalkyl, C1-C5 alkoxy, C1-C5 alkanoyl , C1-C5-alkoxycarbonyl, C1-C5-oxy alkanoyl, aminocarbonyloxy, C1-C5-aminocarbonyloxy, C1-C5-alkylcarbonyloxy, aminocarbonyl, C1-C5-alkylcarbonyl, C1-C5-aminocarbonyl, C1- alkanoyl C5-amino, C1-C5-carbonylamino alkoxy, C1-C5-sulfonylamino alkyl, C1-C5-aminosulfonyl alkyl, C1-C5-alkyl dialkylsulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, nitro, amino with a nitrogen atom mono- or disubstituted, wherein the substituents on the nitrogen are, independently of each other, C1-C5 alkyl or ar ilo or ureido, wherein each nitrogen is independently substituted with C1-C5 alkyl or C1-C5-thio alkyl, wherein the sulfur can be optionally oxidized in a sulfoxide or sulfone, or its tautomers, prodrugs, solvates or salts for the therapy and prevention of gynecological diseases such as endometriosis, uteri leiomionas, dysfunctional hemorrhages and dysmenorrhea. |
| priorityDate | 2005-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 37.