| abstract |
Compounds of formula (1), wherein R1 is O, (H, H), (H, OH) or NOR, where R is hydrogen, C1-6 alkyl or C1-6 acyl; R2 is hydrogen, methyl, ethyl or ethenyl; R3 is hydrogen, methyl, ethyl, ethenyl, fluorine or chlorine; R4 is methyl or ethyl; R5 is hydrogen, methyl or ethyl; R6 is hydrogen, methyl, ethyl, C2-3 alkenyl or C2-3 alkynyl; R7 is hydrogen or C1-15 acyl and at least one of R5 or R6 is hydrogen; or a pharmaceutically acceptable salt thereof, for use as a medicament for a treatment to increase androgen levels, for androgen supplementation, for testosterone replacement and for benign prostatic hypertrophy, and a method of male contraception, preferably as a unique means to achieve a progestagenic sterilizing effect and also androgen supplementation. |