http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-054047-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| filingDate | 2006-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdf3615ff750b63c0501b0137043d4b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eac882e27f0f0e850ad2d25aecd8421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed4c2fe6bc87795198ceaeb08eaf318d |
| publicationDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-054047-A1 |
| titleOfInvention | PHENYLQUINAZOLINE DERIVATIVES |
| abstract | New phenylquinazoline derivatives of the formula (1) wherein R1 is Hal, OH; OA, SH, SA, H or A, R2 and R3 are in each case, independently of each other, -O- (X) sQ, -S- (X) sQ, -NHCO- (X) s -Q, -CONH- (X) s -Q, -CONA- (X) sQ, NH (CO) NH- (X) sQ, - NH (CO) O- (X) sQ, -NHSO2- (X) sQ, - SO2NH- (X) sQ, -SO2NA- (X) sQ, NHCOA, Hal, Het or H, where, in the case where R2 = H, then R3 is different H, or in case R3 = H, then R2 is different from H, R4, R5 are in each case, independently of each other, H, Hal, CN, NO2, A, OH, OA, SH, SA, (CH2) nCOOH, (CH2) nCOOA, O (CH2) 0CONH2, CONHA, CONNA ', NH2, NHA, NAA', NHCOOA, NHCO (CH2) nNH2, NHCONHA, SOA, SO2A; SO2NH2, SO2NHA, SO2NAA 'or O (CH2) 0Het1, two adjacent radicals, selected from the group R1, R2, R3, are also together methylenedioxy or ethylenedioxy, A, A' are in each case, independently of each other unbranched alkyl or branched with 1-10 atoms of C, where 1-5 atoms of H can be replaced by F, Cl and / or Br, Alk or cyclic alkyl with 3-7 atoms of C, A and A 'are also together a alkylene chain with 2, 3, 4, 5 or 6 C atoms, wherein one or two CH2 groups, may be replaced by O, S, SO, SO2; NH, NA and / or N-COOA, Alk is alkenyl with 2-6 C atoms, X is C1-10 alkylene or unbranched or branched C2-C10 alkenylene or mono-, di-, tri-tetrasubstituted with A , OA, OH, SH, SA, Hal, NO2, CN, Ar, O ar, COOH, COOA, CHO, C (= O) A, C (= O) Ar, SO2A, CONH2, SO2NH2, CONHA, XONNA ' , SO2NHA, SO2NAA ?, NH2, NHA, NAA'OCONH2, OCONHA, OCONAA ', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONH2, NHCONHA, NACONHA; NHCONAA ', NACONAA', and / u = O, where also one, two or three C groups may be replaced by O, S, SO, SO2, NCO, NACO, CONH, CONA, SO2NH, SO2NA, NHSO2, NASO2 and / or by NH groups, Q is H, Carb, Ar or Het, Carb is cycloalkyl with 3-7 C atoms or cycloalkenyl with 3-7 unsubstituted or mono-, di, tri-, tetra- or pentasubstituted C atoms with A, OA, OH, SH, SA, Hal, NO2; CN, (CH2) nAr ', (CH2) nCOOH, (CH2) nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA ', NH2, NHA, NAA', OCONH2, OCONHA, OCONAA ', NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH, NACONH2, NHCONHA, NACONHA, NHCONAA' and / or NACONAA ', Ar is phenyl, naphthyl or biphenyl unsubstituted or mono-, di-, tri-, tetra- or Penta substituted with A, OA, OH, SH, SA, Hal, NO2, CN (CH2) nAr ', (CH2) nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA', SO2NHA, SO2NAA ', NH2, NHA, NAA ', OCoN2; OCONHA, OCONAA ', NHCOA, NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA; NACONHA, NHCONAA ', NACONAA', and / or tetraazole, Ar 'is phenyl, naphthyl or unsubstituted biphenyl or mono-, di- or trisubstituted with A, OA, OH, SH, SA, Hal, NO2, CH, (CH2 ) n phenyl, (CH2) nCOOH, (CH2) nCOOA, CHO, COA, SO2A, CONH2, SO2NH2, CONHA, CONAA ', SO2NHA, SO2NAA', NH2, NHA, NAA ', OCONH2, OCONHA, OCONAA', NHCOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHCONAA 'and / or NACONAA', Het is a mono-, or bicyclic saturated, unsaturated or aromatic heterocycle with 1 to 4 atoms of N, O and / or S, which may be mono-, di or trisubstituted with A, OA, OH, SH, SA, Hal, NO2, CN, (CH2) nAr ', (CH2) nCOOH, (CH2) nCOOA, CHO, COA, SO2A, CONH2, SO2nH2, CONHA, CONNA ', SO2NHA, SO2NAA', NH2, NHA, NAA ', OCONH2, OCONHA, OCONAA, NHCOA, NHCOOA, NACOOA, NHSO2OA, NASO2OA, NHCONH2, NACONH2, NHCONHA, NACONHA, NHACAA, NHAONA, NHAONA, NHAONA, NHAONA , = S, = NH, = NA and / u = O (carbonyl oxygen) ,, Het1 a saturated, unsaturated or aromatic monocyclic heterocycle with 1 to 2 atoms of N and / or O, which may be mono- or disubstituted with A, OA, OH, Hal and / u = O (oxygen carbonyl), Hal is F Cl, Br, or I, n is 0, 1, 2, 3, or 4, or is 1, 2, or 3 , s is 0, 1 or 2, as well as its derivatives, salts, solvates, tautomers and stereoisomers of pharmaceutical utility, including mixtures in all proportions. They are HSP90 inhibitors and can be used to prepare a medicine for the treatment of diseases in which the inhibition, regulation and / or modulation of HSP90 plays an important role. |
| priorityDate | 2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.