http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-054031-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 |
| filingDate | 2006-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-054031-A1 |
| titleOfInvention | LIGHTWEIGHT ACILAMINOBICICLIC COMPOUNDS OF CANNABINOID RECEPTORS |
| abstract | Pharmaceutical compositions containing them and use as anti-inflammatory agents. Claim 1: A compound of formula (1) wherein R1 and R2 are each independently an aryl optionally substituted with one or more substituents, or a heteroaryl optionally substituted with one or more substituents; V is O and W is CR3aR3b, or V is CR3aR3b and W is N-R4; R3a, R3b, R5a, R5b, R6a, R6b, and R7a are each independently H, C1-4 alkyl, or halogen substituted C1-4 alkyl; R4 is H, C1-4 alkyl, C1-4 alkyl substituted with allogen, (C1-4 alkoxy) -C (O) -, aryl, (C1-4 alkyl) -C (O) -, (aryl) -C (O) -, (C1-4 alkyl) -SO2-, or (aryl) -SO2-; R7b is (i) H, (ii) C1-6 alkyl, (iii) C2-6 alkenyl, (iv) C1-4 alkyl substituted by halogen, (v) -C (O) - (CH2) pR8, in the which p is 0 or 1, and R8 is a chemical moiety selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C1-4 alkoxy, C3-7 cycloalkyl, C1-4 alkyl-SO2-, heterocycle of 3 to 6 members containing 1 to 3 heteroatoms independently selected from O, N and S, lactam or lactone of 5 to 6 members and 5 to 6 member heteroaryl containing 1 to 3 heteroatoms independently selected from O, N and S, wherein said chemical moiety is optionally substituted with one or more substituents selected from C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl, halo, cyano, amino, C 1-4 alkyl, or di-alkyl C1-4-amino; or R8 considered together with R7a form a 5 to 6 member lactam; (vi) -C (O) -O-R9, wherein R9 is C1-6 alkyl, C1-6 alkyl substituted with halogen or C1-4 alkoxy-C1-6 alkyl; or R9 considered together with R7a form a 5 to 6 member lactone, or (vii) -C (O) -N (R10a) (R10b) in which R10a is H, C1-6 alkyl, or substituted C1-4 alkyl with halogen, and R10b is H, C1-6 alkyl, halogen substituted C1-4 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, 3 to 6 membered heterocycle containing 1 to 3 heteroatoms independently selected from O , N and S, lactam or lactone of 5 to 6 members, and heteroaryl of 5 to 6 members containing from one to three heteroatoms independently selected from O, N and S, wherein said chemical moiety is optionally substituted with one or more substituents selected from C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl, halo, cyano, amino, C 1-4 alkyl, or di-C 1-4 alkyl, or R 10a and R 10b taken together form a piperidine or a pyrrolidine, either R10a or R10b taken together with R7a form a 5 to 6 member lactam; or a pharmaceutically acceptable salt thereof, or a solvate or hydrate of the compound or salt. |
| priorityDate | 2005-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.