http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-053725-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| filingDate | 2006-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17b403259324e21efee1cf68444ff623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bc3f1deae0c83258c93ca7208a24bf5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b0be39d86fdd9a246d84032235f6c66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc1266abfb60b6fc8028cce9c61cc07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_286f1b28b39d9f11cdca4845dbfef7ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33e8e7f9141c37c4ddcf8498659de35d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d68329245c04586720406f075c93941f |
| publicationDate | 2007-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-053725-A1 |
| titleOfInvention | BASIC TRICICLIC COMPOUNDS 1,6-DIHIDRO-1,3,5,6-TETRAAZA-AS-INDACENO AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THE SAME |
| abstract | Claim 1: A compound characterized in that it has the formula (1), or salts thereof wherein: R1 is selected from hydrogen, C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl; R2 is selected from hydrogen, halo, alkyl, alkenyl, alkynyl and perfluoroalkyl; R5 is selected from: hydrogen and halo; alkyl, alkenyl, alkynyl and haloalkyl, any of which may be optionally independently substituted as permitted in Valencia with one or more Z1b, Z2b and Z3b; -OR11, -SR11 and -NR3R4; R3 and R4 are independently selected from: hydrogen; alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl or (heteroaryl) alkyl any of which may be optionally independently substituted as valence permits with one or more of Z1b, Z2b and Z3b; -OR11, -NR12R13, -N (R12) C (O) R14, - N (R12) C (O) OR14, -N (R12) SO2R14, -N (R12) C (O) NR12aR13, - N (R12 ) SO2NR12aR13, -C (O) NR12R13, -SO2R14, or -SO2NR12R13; R3 and R4 together with the nitrogen atom to which they are combined combined to form an optionally independently substituted 3 to 8 heterocyclic ring as valence allows it with one or more Z1b, Z2b and Z3b; R6 is: alkyl, alkenyl, alkynyl, any of which is substituted with one or more as the valence allows Z1f; cycloalkyl, heterocycle, aryl, heteroaryl, (cycloalkyl) alkyl, (heterocycle) alkyl, (aryl) alkyl, or (heteroaryl) alkyl any of which can be optionally independently substituted as the valence allows it with one or more of Z1d, Z2d and Z3d; or -SR7a, -SO2R10, -SO2NR8bR9b, C (O) R7a, -C (O) OR7a, or -C (O) NR8aR9a; R7 is: hydrogen, halo, or cyano; alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, (cycloalkyl) alkyl, (heterocycle) alkyl, (aryl) alkyl, or (heteroaryl) alkyl any of which may be optionally independently substituted as valence permits with one or more of Z1c, Z2c and Z3c; or R7a is independently: hydrogen; or alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which may be optionally independently substituted as the valence allows with one or more of Z1c, Z2c and Z3c; R8 is: hydrogen; alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which may be optionally independently substituted as valence permits with one or more of Z1d, Z2d and Z3d; or -SO2R10, - SO2NR8bR9b, -C (O) OR7a, or -C (O) NR8aR9a; R8a, R8b, R9a and R9b are independently: hydrogen; alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which may be optionally independently substituted as valence permits with one or more of Z1d, Z2d and Z3d; R8a, and R9a, together with the nitrogen atom to which they bind, combine to form a heterocyclic ring of 3 to 8 optionally independently substituted members as valence permits with one or more of Z1b, Z2b and Z3b; or R8b and R9b together with the nitrogen atom to which they bind combine to form an optionally independently substituted 3 to 8-membered heterocyclic ring as valence allows with one or more of Z1b, Z2b and Z3b; R10, each time it occurs, is independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which they can be optionally independently substituted as the valence allows it with one or more of Z1d, Z2d and Z3d; R11, R12, R12a and R13 are independently: hydrogen; or alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which may be optionally independently substituted as the valence allow with one or more Z1e, Z2e and Z3e; R14 is alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, (cycloalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl any of which may be optionally independently substituted as valence allow it with one or more Z1e, Z2e and Z3e; Z1a-1e, Z2a-2e, and Z3a-3e are optional substituents whenever presented independently selected from -W1-V1; -W2-V2; -W3-V3; -W4-V4; -W5-V5; where W1-5 are independently: H; alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl, any of which may be optionally independently substituted as valence permits with one or more of V1-5; or where V1-5 are independently: H; alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl, any of which may be optionally independently substituted as valence permits with one or more of the groups of V1-5, which are: -U1-OY5, -U1-S-Y5; - U1-C (O) t-H, -U1-C (O) t-Y5, where t is 1 or 2; -U1-SO3-H, or -U1-S (O) tY5; -U1-halo; -U1-cyano; -U1-nitro; -U1-NY2Y3; -U1-N (Y4) -C (O) -Y1; -U1-N (Y4) -C (S) -Y1; -U1- N (Y4) -C (O) -NY2Y3; -U1-N (Y4) -C (O) -C (O) -NY2Y3; -U1-N (Y4) -C (O) -C (O) -OY5; -U1-N (Y4) -C (S) -NY2Y3; -U1- N (Y4) -C (O) O-Y5; -U1-N (Y4) -S (O) 2-Y1; -U1-N (Y4) -S (O) 2-NY2Y3; -U1-C (O) -NY2Y3; -U1-OC (O) -NY2Y3; -U1-OC (O) -OY5; -U1-S (O) 2-N (Y4) - Y1; -U1-N (Y4) -C (-NV1a) -NY2Y3; - U1-N (Y4) -C (-NV1a) -Y1; -U1-C (-NV1a) -NY2Y3, oxo; -U1-Y5; Z1f, each time it is presented, is independently selected from: cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cyclolalkyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl, optionally substituted as valence permits with one or more of the groups, which are: alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl, U1-OY5, -U1-S-Y5; -U1-C (O) t- H, -U1-C (O) t-Y5, where t is 1 or 2; -U1-SO3-H, or -U1-S (O) tY5; -U1-halo; -U1-cyano; -U1-nitro; -U1-NY2Y3; -U1-N (Y4) -C (O) -Y1; -U1- N (Y4) -C (S) -Y1; -U1-N (Y4) -C (O) -NY2Y3; -U1-N (Y4) -C (O) -C (O) -NY2Y3; -U1-N (Y4) -C (O) -OY5; -U1-N (Y4) -S (O) 2-Y1; -U1-N (Y4) -S (O) 2- NY2Y3; (18) -U1-C (O) -NY2Y3; -U1-OC (O) -NY2Y3; -U1-S (O) 2-N (Y4) -Y1; - U1-N (Y4) -C (= NV1a) -NY2Y3; -U1-N (Y4) -C (= NV1a) -Y1; -U1-C (= NV1a) -NY2Y3; oxo; -U1-Y5; V1a is independently hydrogen, alkyl, -CN, -C (O) Y1, -S (O) 2Y5, -C (O) NY2Y3, S (O) 2NY2Y3; Y1, Y2, Y3, Y4 and Y5: each is independently hydrogen, alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl, ) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl, any of which may be optionally independently substituted as the valence permits with one or more of Z4, Z5 and Z6; or Y2 and Y3 together with the nitrogen atom to which they bind combine to form an optionally independently substituted 3 to 8-membered heterocyclic ring as the valence allows with one or more of Z4, Z5 and Z6; or Y2 and Y3 together with the nitrogen atom to which they are linked can be combined to form a group -N = CY6Y7 where Y6 and Y7 are each independently H or alkyl; and Z4, Z5, and Z6 are optional substituents whenever presented independently selected from: H; alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) I rent; -U1-O-Y5a; -U1-S-Y5a; -U1-C (O) t-H, -U1-C (O) t-Y5a where t is 1 or 2; -U1-SO3-H, or -U1-S (O) tY5a; -U1-halo, -U1-cyano; - U1-nitro; -U1-NY2aY3a; -U1-N (Y4a) -C (O) -Y1a; -U1-N (Y4a) -C (S) - Y1a; -U1-N (Y4a) -C (O) -NY2aY3a; -U1-N (Y4a) -C (S) -NY2aY3a; -U1-N (Y4a) -C (O) O-Y5a; -U1-N (Y4a) -S (O) 2-Y1a; -U1-N (Y4a) -S (O) 2- NY2aY3a; -U1-C (O) -NY2aY3a; -U1-OC (O) -NY2aY3a; -U1-S (O) 2-N (Y4a) -Y1a; -U1- N (Y4a) -C (-NV1b) -NY2aY3a; -U1-N (Y4a) -C (= NV1b) -Y1a; -U1-C (= NV1b) -NY2aY3a; oxo; -U1-Y5a; V1b is independently hydrogen, alkyl, -CN, -C (O) Y1a, -S (O) 2Y5a, S (O) 2NY2aY3a; Y1a, Y2a, Y3a, Y4a and Y5a: each is independently hydrogen, alkyl, (hydroxy) alkyl, (alkoxy) alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl) alkyl, cycloalkenyl, (cycloalkenyl) alkyl, aryl, (aryl ) alkyl, heterocycle, (heterocycle) alkyl, heteroaryl, or (heteroaryl) alkyl; U1 is independently: a single link; alkylene; alkenylene; or alkynylene. |
| priorityDate | 2005-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.