http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-053526-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2901e694724c2a759f619944cb7d2a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| filingDate | 2005-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-053526-A1 |
| titleOfInvention | ARILCICLOALQUI-SUBSTITUTED ALCANOIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR PREPARATION |
| abstract | Arylcycloalkyl-substituted alkanoic acid derivatives, procedures for their preparation and use as pharmaceutical products. It refers to arylcycloalkyl substituted alkanoic acid derivatives, their physiologically acceptable salts and their physiologically operational derivatives. The compounds of formula 1, a pharmaceutical composition based on it and a process for preparing them are described. Procedures for its preparation. The compounds are suitable, for example, for the treatment and / or prevention of disorders of fatty acid metabolism and glucose utilization disorders and also of disorders in which insulin resistance such as diabetes is involved. type 2. Claim 1: A compound of formula 1 wherein the A ring is cycloalkanediyl- (C3-8) or cycloalkenodiyl- (C3-8), wherein in the cycloalkanediyl or cycloalkenodiyl rings one or more carbon atoms can be substituted by oxygen atoms; R1 and R2 independently of each other are H, F, Cl, Br, CF3, OCF3, alkyl- (C1-6), O-alkyl- (C1-6), SCF3, SF5, OCF2-CHF2, aryl- (C6 -10), aryloxy- (C6-10), OH, NO2; or R1 and R2 together with the phenyl, pyridine, 1-H-pyrrole, thiophene or furan ring are fused, aryl- (C6-10), heteroaryl- (C5-11) partially saturated or instilled bicyclics; R3 is H, alkyl- (C1-6), cycloalkyl- (C3-8), alkyl- (C1-3) -cycloalkyl- (C3-8), phenyl, alkyl-phenyl- (C1-3), heteroaryl- (C5-6), alkyl- (C1-3) -heteroaryl- (C5-6) or alkyl- (C1-3) which is completely or partially substituted by F; W is CH, N if o = 1; W is O, S, NR9, if o = 0; X is alkanediyl- (C1-6), in which in the alkanediyl group one or more carbon atoms may be substituted by oxygen atoms; Y is CO, SO, SO2; n is 0 to 2; R4 is H, F, alkyl- (C1-6); R5 is H, F, alkyl- (C1-6); R6 is H, F, alkyl- (C1-6); R5 and R6 together with the carbon atoms that carry them are cycloalkano- (C3-8) -1,2-diyl; R7 is H, alkyl- (C1-6), alkenyl- (C2-6), alkynyl- (C2-6), O-alkyl- (C1-6), O-alkenyl- (C2-6), O- alkynyl- (C2-6), cycloalkyl- (C3-8), aryl- (C6-10), heteroaryl- (C5-11), O-cycloalkyl- (C3-8), O-phenyl, NR10R11 which may be substituted by O-alkyl- (C1-6), O-alkenyl- (C2-6), O-alkynyl- (C2-6), O-cycloalkyl- (C3-8), O-phenyl, O-heteroaryl- (C5-11), and in which cycloalkyl- (C3-8), phenyl and heteroaryl- (C5-11) can also be substituted by alkyl- (C1-6), unsubstituted or totally or partially substituted by F, O-alkyl- (C1-6), unsubstituted or wholly or partially substituted by F, Cl, Br, I, OH, NR10R11, CO-alkyl- (C1-6), CO-aryl- (C6-10), CO-heteroaryl- (C5-11), C (O) -O-alkyl- (C1-6), C (O) -O-aryl- (C6-10), C (O) - O-heteroaryl- ( C5-11), SO2-alkyl- (C1-6), SO2-aryl- (C6-10), SO2-heteroaryl- (C5-11), and the alkyl, aryl and heteroaryl may also be substituted by alkyl- (C1 -6) or phenyl; R6 and R7 together with the carbon atom that carry them are cycloalkane- (C3-8) -1,1-diyl; R8 is H, alkyl- (C1-6); R9 is H, (C1-6) alkyl which is unsubstituted or substituted by phenyl and phenyl; R10 is H, alkyl- (C1-6), phenyl, CO-alkyl- (C1-6), CO-aryl- (C6-10), CO-alkyl- (C1-6) -aryl (C6-10) , CO- heteroaryl- (C5-11), SO2-alkyl- (C1-6), SO2-alkyl- (C1-6) -aryl- (C6-10), SO2- alkyl- (C1-6) -SO2 -alkyl- (C1-6), SO2-aryl- (C1-10), SO2-heteroaryl- (C5-11), which may also be alkyl, aryl and heteroaryl substituted by alkyl- (C1-6) or phenyl: R11 it is H, C 1-6 alkyl which is unsubstituted or substituted by phenyl, phenyl; R12 is H, benzyl; or a physiologically acceptable salt, solvate or one of its physiologically functional derivatives. |
| priorityDate | 2004-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.