| abstract |
Method of preparation, pharmaceutical compositions containing them and uses in therapeutics. Claim 1: A compound that responds to formula (1) in which: X represents a group -C (O) -, -SO-, -SO2, -C (O) -N (R6) -, - C ( O) -O-; R1 represents C1-7 alkyl, a non-aromatic C3-12 carbocyclic radical unsubstituted or substituted once or several times with a C1-4 alkyl; C3-7-cycloalkyl unsubstituted or substituted once or several times on the carbocycle with a C1-4 alkyl; an unsubstituted or mono-, di- or trisubstituted phenyl with substituents independently selected from a halogen atom, C1-4 alkyl, C1-4 alkoxy, C1-4-alkyl, di-C1-4-alkyl, cyano, a trifluoromethyl radical, trifluoromethoxy, an S (O) nAlk group, a C1-4 alkylcarbonyl group, or between a phenyl, phenoxy, pyrrolyl, imidazolyl, pyridyl or pyrazolyl radical, said radicals being unsubstituted or substituted once or several times with a C1-4 alkyl, unsubstituted or mono- or disubstituted benzyl on the phenyl with substituents independently selected from a halogen atom, C1-4 alkyl, C1-4m alkoxy trifluoromethyl or substituted in alpha with one or two similar or different groups selected between C1-4 alkyl C3-7 cycloalkyl; phenethyl unsubstituted or mono- or disubstituted on the phenyl with substituents independently selected from a halogen atom, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, benzidrile, benzydrylmethyl, an aromatic heterocyclic radical selected from a pyrrolyl, imidazolyl, furyl, thienyl, pyrazolyl, indolyl unsubstituted or substituted once or several times with substituents independently selected from a halogen atom, C 1-4 alkyl or trifluoromethyl, R 2 represents H or C 1-3 alkyl; R3 represents C1-5 alkyl or C3-7 cycloalkyl; R4 represents unsubstituted or mono-, di- or trisubstituted phenyl with substituents independently selected from a halogen atom, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl or an S (O) nAlk group; R 5 represents unsubstituted or mono-, di- or trisubstituted phenyl with substituents independently selected from a halogen atom, C 1-4 alkyl, C 1-4 alkoxy trifluoromethyl or an S (O) nAlk group; R6 represents an atom of H or C1-3 alkyl; n represents 0, 1 or 2; Alk represents C1-4 alkyl, as well as its hydrates or solvates. |