http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-052559-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b70512b2076a2759fccaecf9fe962d5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| filingDate | 2006-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-052559-A1 |
| titleOfInvention | PIRAZOL DERIVATIVES TO INHIBIT CDK'S AND GSK'S |
| abstract | Pyrazole derivatives herein are useful for inhibiting abnormal cell development. Claim 1: A compound of the formula (1) or a salt, tautomer, solvate or N-oxides thereof in which: R1 is selected from: (a) 2,6-dichlorophenyl; (b) 2,6-difluorphenyl; (c) A 2,3,6-trisubstituted group in which the substituents of the phenyl group are selected from F, Cl, methyl and methoxy and (d) an R0 group where R0 is a carbocyclic or heterocyclic group consisting of 3 a 12 ring members or a C1-8 hydrocarbyl group optionally substituted with one or more substituents selected from F, hydroxy, cyano, C1-4 hydrocarbyloxy, amino, mono or C1-4 hydrocarbylamino and carbocyclic or heterocyclic groups with 3 to 12 ring members and where 1 or 2 of the C atoms of the hydrocarbyl group may be optionally replaced with an atom or group selected from O, S, NH, SO, SO2; (e) each of R2a and R2b is H or methyl, (f) and where: A when R1 is (a) 2,6-dichlorophenyl and both R2a and Rb are H, then R3 can be (i) a group of formula (2), (g) where R4 is C1-4 alkyl and B when R1 is (a) 2,6-difluorphenyl and both R2a and Rb are H, then R3 can be: (ii) a 4- piperidinyl group N -substituted in which the substituent N is C1-4 alkoxycarbonyl, and C when R1 is (c) a 2,3,6-trisubstituted phenyl group in which the substituents of the phenyl group are selected from F, Cl, methyl and methoxy and both R2a and Rb are H, then R3 can be selected from groups (i) and (iii) defined herein; D when R1 is (d) a group R0, where R0 is a carbocyclic or heterocyclic group consisting of 3 to 12 ring members or a C1-8 hydrocarbyl group optionally substituted with one or more substituents selected from F, hydroxy, cyano, C1-4 hydrocarbyloxy, amino, mono or di-C1-4 hydrocarbylamino and carbocyclic or heterocyclic groups with 3 to 12 ring members and where 1 or 2 of the C atoms of the hydrocarbyl group can be optionally replaced with an atom or group selected from O, S, NH, SO, SO2, then R3 may be (iii) a group of formula (3) in which R7a is selected from: unsubstituted C1-4 hydrocarbyl other than C1-4 alkyl, C1-4 hydrocarbyl substituted with one or more substituents selected from C3-6 cycloalkyl, F, Cl, methylsulfonyl, acetoxy, cyano, methoxy and an NR5R6 group and a group - (CH2) n-R8 in which n is 0 or 1 and R8 is selected from C3-6 cycloalkyl, C4-6 oxa-cycloalkyl, phenyl optionally substituted with one or more s substituents selected from F, Cl, methoxy, cyano, methyl and trifluoromethyl; an aza-bicycloalkyl group and a 5-membered heteroaryl group containing one or two ring members that are heteroatoms selected from O, N and S and that is optionally substituted with methyl, methoxy, F, Cl or an NR5R6 group; but excluding the compound 4 {[4- (2,6-dichloro-benzoylamino) -1 H -pyrazol-3-carbonyl] -amino} -piperidine-1-carboxylic acid tert-butyl ester. |
| priorityDate | 2005-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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