http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-052419-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aeeae3a1e9c2f6b4db133adad89691b1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| filingDate | 2005-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-052419-A1 |
| titleOfInvention | DERIVATIVES OF BENCIMIDAZOLIL N-SUBSTITUTES, INHIBITORS OF THE PROTOONCOGEN C-KIT |
| abstract | Pharmaceutical compositions containing them, uses as anticancer and combinatorial benzimidazole banks. Claim 1: A compound represented by formula (1) or a pharmaceutically acceptable salt or N-oxide thereof, wherein: R1 and R2 are independently C0-8 alkyl optionally substituted with a heterocyclyl substituent; C0-8 alkyl optionally substituted with an independent halo 1-6, -CONR11R12, -NR13CONR11R12, -NR13CO2R11, -S (O) 0-2NR11R12, -NR11S (O) 0-2R12, CN, OH, or substituted aryl substituents optionally; -C0-8alkyl-C3-8cycloalkyl; -C0-8alkyl-O-C0-8alkyl-, -C0-8alkyl- N (C0-8alkyl) (C0-8alkyl), -C0-8alkyl-S (O) 0-2-C0-8alkyl-; or heterocyclyl optionally substituted with cyclyl, C0-8alkyl independent 1-4, or substituted cyclyl substituents; or R1 and R2, taken together with the N to which they are attached, form a heterocyclic group, optionally substituted with C0-8alkyl, -C0-8alkyl-O-C0-8alkyl-, -C0-8alkyl-independent groups 1- 4, or -C0-8alkyl-heteroaryl groups, provided that the heterocyclic group that is formed is not piperazine; R3 is an aryl or heteroaryl group, optionally substituted with C0-8alkyl, C0-8alkylcycloyl, halo, OH, -NR31S (O) 0-2R32, - (O) 0-2NR31R32, -NR31COR32, -NR31CONR32R33, - CONR31R32 , S (O) 0-2R31, O-aryl, -O-hetaryl, NO2, CN, CF3, OCF3, OCHF2; independent 1-4; R11, R12, R13, R31, R32, and R33 are each independently C0-8alkyl optionally substituted with a heterocyclyl substituent, C0-8alkyl optionally substituted with a halo -CON (C0-8alkyl) (C0-8alkyl), -N (C0-8alkyl) WITH (C0-8alkyl) (C0-8alkyl), -N (C0-8alkyl) CO2 (C0-8alkyl), S (O) 0-2N (C0-8alkyl) (C0-8alkyl), - NR11S (O) 0-2 (C0-8alkyl), CN, OH, independent 1-6, or optionally substituted aryl substituents; -C0-8alkyl-C3-8cycloalkyl; -C0-8alkyl-O-C0-8alkyl-, -C0-8alkyl-N (C0-8alkyl) (C0-8alkyl), -C0-8alkyl-S (O) 0-2-C0-8alkyl-; or heterocyclyl optionally substituted with cyclyl, C0-8alkyl independent 1-4, or substituted cyclyl substituents; and provided that R3 is not a tetrazolyl, 5-pyrimidinyl, or 4-biphenyl group. |
| priorityDate | 2004-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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