http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-051940-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4b14e936224599e9ceef6151c235adf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 |
| filingDate | 2005-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_355f540f679497aaa333bfe30ab0a988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_023430e9454679bffd1bfd1f74a78b87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_943595d86379d25f9db48e89e6c53784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5795b6af5705b20378d9f899275530c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83dd730a4e377e98f9e9dd818ab5c6f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c1d9d5135e5d1646b936be1c513c202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_913625852ff84e117847dd96ea49439e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3f50c2c263f8cf623d973826a56d3ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a660e16b91e98203ed4ec13541ca36f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_641ca55b9e998bb147ee44d2d7696816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_724bcd4933e3aed59f9a45675c29e4f6 |
| publicationDate | 2007-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-051940-A1 |
| titleOfInvention | COMPOUNDS AND METHODS TO MODULATE THE ACTIVITY OF THROMBOPOYETINE |
| abstract | Arylhydrazino substituted compounds, pharmaceutical compositions comprising them, methods that use them to modulate the activity of a thrombopoietin receptor, methods for identifying compounds as thrombopoietin receptor modulators, and methods for treating a disease by administering a compound of the present to a patient You need such treatment. Claim 1: A compound characterized in that it responds to the formula (1), or a salt, an ester, an amide or a prodrug acceptable for pharmaceutical use thereof, wherein: R1 is selected from CO2R10, CONR10R11, SO3R10, and a bioisostero of carboxylic acid; R2 and R3 are independently selected from each other from absent, hydrogen, OR12, NR12R13, optionally substituted C1-4 aliphatic, optionally substituted C1-4 haloaliphatic, optionally substituted C1-4 heteroaliphatic, optionally substituted ring, and (CH2) mR14 ; or R2 and R3 taken together form an optionally substituted olefin; or R2 and R3 join to form an optionally substituted C3-6 ring; R4 is selected from hydrogen, F, Cl, Br, C1-4 aliphatic, C1-4 haloaliphatic, C1-4 heteroaliphatic, and a ring; R5 is selected from hydrogen, OR10, SR10, NHR11, and CO2H; R6 is selected from hydrogen, OR12, NR12R13, F, Cl, Br, C1-4 alkyl, C1-4 haloalkyl, C1-4 heteroalkyl, and a ring; R7 is selected from hydrogen, optionally substituted C1-8 aliphatic, optionally substituted C1-8 haloaliphatic, optionally substituted C1-6 heteroaliphatic, optionally substituted C1-8 heterohaloaliphatic, optionally substituted ring, and (CH2) mR14; R10 is selected from hydrogen, optionally substituted C1-4 aliphatic, C1-4 haloaliphatic, C1-4 heteroaliphatic, and a ring; R11 is selected from hydrogen, SO2R15, C1-4 aliphatic, C1-4 haloaliphatic, C1-4 heteroaliphatic, and a ring; R112 and R13 are independently selected from each other from hydrogen, optionally substituted C1-4 aliphatic, optionally substituted C1-4 haloaliphatic, optionally substituted C1-4 heteroaliphatic, an optionally substituted ring, and (CH2) mR14; or one of R12 and R13 is optionally substituted C2-6 aliphatic or an optionally substituted ring and the other of R12 and R13 is absent; or R12 and R13 join to form an optionally substituted C3-8 ring; R14 is selected from an optionally substituted aryl and an optionally substituted heteroaryl; R15 is selected from hydrogen, C1-3 aliphatic, C1-3 haloaliphatic, and a ring; Y is a 1-4 atom separator comprising one or more groups selected from an optionally substituted C1-6 aliphatic, optionally substituted C1-6 heteroaliphatic, an optionally substituted phenyl, an optionally substituted heteroaryl, optionally substituted C3-5 heterocycle, and an optionally substituted alicyclic; with the proviso that Y is not -N = CR6- oriented to form a dihydropyrazole; Z is selected from: a separator of 2-5 atoms selected from an optionally substituted C6-10 aryl and optionally substituted C1-6 heteroaryl; and a 1-5 atom separator selected from optionally substituted C1-6 aliphatic, optionally substituted C1-6 heteroaliphatic, and optionally substituted C1-6 haloaliphatic; m is 0, 1, or 2; and n is 0 or 1. |
| priorityDate | 2004-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.