http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-051457-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a48132fcc2f50a7107021f911f887cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 |
| filingDate | 2005-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6df9ee1ea4de6a18e00bfe7980032f8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b0f84b30aaa494695ce94c9e242d3d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55cde34f0bb01da6340bedebef416c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e80384df543b4a93594b26c0641d3de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3170e61892f7aa425e74fc601dc10863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45123c9e8ddea88fcf3323700bd86c8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d331e46ab3accb7dfbf5232cdbee78ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4a825ad9c8db7e895d3d7e58187b8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fcb39b4caabf6e81d7aa55e8f7edc07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a29eea1751a407c5b5c8fb5d629dbd6 |
| publicationDate | 2007-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-051457-A1 |
| titleOfInvention | INDAZOLES, BENZISOXAZOLES AND BENZISOTIAZOLES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS AND ITS USE AS A STROGEN AGENT |
| abstract | The compounds are modulators of estrogen receptors. Claim 1: A compound of formula (1), or an acid addition salt or a stereoisomeric form thereof; characterized in that: R1 is hydrogen or a C1-6 alkyl, C3-6 cycloalkyl, trifluoromethyl, -N = NCR5R6, -SO2NR7R8, phenyl, phenylC1-3alkyl or C1-3 alkyl substituted by a saturated heterocyclic radical, where the phenyl is unsubstituted or substituted by at least one substituent selected from the group consisting of a hydroxyl, a halogen, nitro, a cyano, a C1-3 alkyl, a C1-3 alkoxy and a trifluoromethyl; R1 may also be a salt; each of R2 and R3 is independently a hydrogen group or a hydroxyl, halogen, nitro, cyano, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, trifluoromethyl, -NR7R8, -CONR7R8, -COR9 or -CO2R9; R2 may also be a phenyl or a saturated or unsaturated heterocycle, where the phenyl is unsubstituted or substituted by at least one substituent selected from the group consisting of hydroxyl, halogen, nitro, cyano, C1-3 alkyl, C1-3 alkoxy, trifluoromethyl a saturated heterocyclic radical; X is O, S, SO, SO or NR4; R4 is hydrogen or a C1-6 alkyl, C3-6 cycloalkyl, phenyl, phenylC1-3alkyl, C1-3 alkyl group substituted by a saturated heterocyclic radical, a group -COR7, -CO2R7 or -SO2NR7R8, where the phenyl is unsubstituted or substituted by at least one substituent selected from the group consisting of a hydroxyl, a halogen, a nitro, a cyano, a C1-3 alkyl, a C1-3 alkoxy, a trifluoromethyl, a phenylC1-3alkyl and a phenylC1-3alkoxy; Y is a direct link, O, S, SO, SO2, NR4, CO, - (CR10R11) n- or -R10C = CR11-; each of R5, R6, R7 and R8 is independently hydrogen or a C1-6 alkyl or C3-6 cycloalkyl group; R9 is hydrogen, C1-6 alkyl, phenyl or a saturated or unsaturated heterocyclic radical, where the phenyl is unsubstituted or substituted by at least one substituent selected from the group consisting of hydroxyl, halogen, nitro, cyano, C1-3 alkyl, C1 -3 alkoxy, trifluoromethyl and a saturated heterocyclic radical; each of R10 and R11 is independently hydrogen or a cyano group, C1-6 alkyl, -CO-phenyl, -CO (unsaturated heterocyclic radical) or -CONR7R8, where the phenyl is unsubstituted or is substituted by at least one substituent selected within from the group consisting of hydroxyl, halogen, nitro, cyano, C1-3 alkyl, C1-3 alkoxy and trifluoromethyl; n is 1 or 2; A is C3-15 cycloalkyl, C3-15 cycloalkene, phenyl or naphthyl, where the cycloalkyl or cycloalkene is unsubstituted or substituted by at least one C1-6 alkyl, and where the phenyl or naphthyl is unsubstituted or substituted by at least one substituent selected from the group consisting of hydroxyl, halogen, nitro, cyano, C1-3 alkyl, C1-3 alkoxy and trifluoromethyl; when X is NR4, Y and R2 together with the indazolo ring that carries them can also form a 1H-pyran [4,3,2-cd] indazole; provided that: when X is O, S or NR4, R1 is hydrogen or C1-6 alkyl, C3-6 cycloalkyl or trifluoromethyl, and Y is a direct bond, A is not optionally substituted phenyl or optionally substituted naphthyl; when X is NR4 where R4 is H or C1-6 alkyl and R1O is 6-OCH3, Y is not CO; when X is O, R1O is 6-OH or 6-OCH3, Y is a direct bond and A is cyclopentyl, (R2, R3) or (R3, R2) is different from (H, Cl) at position 4.5 ; when X is O, R1O is 6-OH, R2 and R3 are H and Y is CH = CH, A is not phenyl or 4-methoxyphenyl; when X is SO2, A is phenyl and R1O is 5- or 6-OCH3, (R2, R3) or (R3, R2) is different from (H, OCH3) in position 6- or 5-. |
| priorityDate | 2004-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.