http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050954-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| filingDate | 2005-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050954-A1 |
| titleOfInvention | PROCEDURE TO PREPARE BICYCLE PIRAZOLILO COMPOUNDS |
| abstract | The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases associated with the mediation of cannabinoid receptors in animals. Claim 1: A process for preparing a compound having the formula (1), wherein: R0a, R0b, R1b, and R1c are each independently halo, C1-4 alkoxy, C1-4 alkyl, C1-4 alkyl halosubstituted , or cyano; n and m are each independently 0, 1 or 2; and R4 is a chemical moiety selected from the group consisting of C1-8 alkyl, aryl, heteroaryl, C1-4 arylalkyl, partially or fully saturated carbocyclic ring (s) of 3 to 8 members, heteroarylalkyl C1- 3, 5 to 6 member lactone, 5 to 6 member lactam, and a partially or fully saturated 3 to 8 member heterocycle, wherein said chemical moiety is optionally substituted with one or more substituents; a pharmaceutically acceptable salt thereof, or a solvate or hydrate of said compound or said salt; comprising the steps of: a) protecting the hydroxy group of a compound of formula (2) with a hydroxy protecting group to form a hydroxy-protected compound of formula (2), wherein R0a, R0b, R1b, R1c, n and m are as defined above, and Pg is a hydroxy protecting group; b) reacting the protected hydroxy compound of formula (2) with a compound of formula (3) to form a compound of formula (4), wherein R0a, R0b, R1b, R1c, n, m Pg, and R4 are as defined above; c) converting the hydroxy group of said compound of formula (4) into a leaving group to produce a compound of formula (5), in which R0a, R0b, R1b, R1c, m, n Pg, and R4 are as defined above and L is a leaving group; d) removing said hydroxy protecting group and cycling said compound of formula (5) to form the compound of formula (1); and e) isolating said compound of formula (1), or a pharmaceutically acceptable salt thereof, or a solvate or hydrate of said compound or said salt. |
| priorityDate | 2004-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID454973655 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458397310 |
Total number of triples: 30.