http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050945-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| filingDate | 2005-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82c7c3a77f02f6149abe44a9ed656298 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e9078a30d1e5c0ccf05ea611776a71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_062be24ce35535b975ba9d8bd1a8addd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d54055ed35e81af396496644693ab7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34af450328dd7d686e4081d0dab88740 |
| publicationDate | 2006-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050945-A1 |
| titleOfInvention | MEDICATIONS CONTAINING CARBON COMPOUNDS AND THEIR USE |
| abstract | Use of compound of the formula (1), in which: R1, R2 are each, independently of each other, H, = O, Hal, A, ethynyl, OR3, N (R3) 2, NO2, CN, N3, COOR3, CON (R3) 2, - [C (R4) 2] n-Ar, - [C (R4) 2] n-Het, - [C (R4) 2] n-cycloalkyl, -OCOR3, - OCON (R3) 2, NR3COA or NR3SO2A; R1 and R2 are also together a 3- to 7-membered carbocycle or heterocycle linked in a bicyclic or spirocyclic form with 0 to 3 atoms of N, O and / or S; R3 is H, A, HC ::: C-CH2-, CH3-C ::: C-CH2-, -CH2-CH (OH) -CH2OH, -CH2-CH (OH) -CH2NH2, -CH2- CH (OH) -CH2Het ', - [C (R4) 2] n-Ar', - [C (R4) 2] n-Het ', - [C (R4) 2] n-cycloalkyl, - [C (R4 ) 2] n-COOA or - [C (R4) 2] nN (R4) 2; R4 is H or A; W is N, CR3 or a hybridized C sp2 atom; E is together with W a saturated carbocyclic or heterocyclic ring of 3 to 7 members with 0 to 3 atoms of N, 0 to 2 atoms of O and / or 0 to 2 atoms of S, which may contain a double bond; D is a mono- or bicyclic aromatic carbocycle or heterocycle unsubstituted or mono- or polysubstituted with Hal, A, OR3, N (R3) 2, NO2, CN, COOR3 or CON (R3) 2, with 0 to 4 N atoms , O and / or S; G is - [C (R4) 2] n-, - [C (R4) 2] nNR3, - [C (R4) 2] nO-, - [C (R4) 2] nS- or - [C (R4 ) = C (R4)] n-; X is - [C (R4) 2] nCONR3 [C (R4) 2] n-, - [C (R4) 2] nNR3CO [C (R4) 2] n-; - [C (R4) 2] nNR3 [C (R4) 2] n-, - [C (R4) 2] nO [C (R4) 2] n-, - [C (R4) 2] nCO [C ( R4) 2] n- or - [C (R4) 2] nCOO [C (R4) 2] n-; Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl; T is a saturated or unsaturated mono- or bicyclic carbocycle or heterocycle with 0 to 4 atoms of N, O and / or S, which is mono- or disubstituted with = O, = S, = NR3, = N-CN, = N -NO2, = NOR3, = NCOR3, = NCOOR3, = NOCOR3 and which can also be mono-, di- or trisubstituted with R3, Hal, A, - [C (R4) 2] n-Ar, - [C (R4 ) 2] n-Het, - [C (R4) 2] n-cycloalkyl, OR3, N (R3) 2, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3CON (R3) 2, NR3SO2A, COR3 , SO2NR3 and / or S (O) nA; A is unbranched or branched C1-10 alkyl, wherein one or two CH2 groups may be replaced by O or S atoms and / or by groups -CH = CH and / or 1-7 H atoms may be replaced by F; Ar is phenyl, naphthyl or biphenyl unsubstituted or mono-, di- or trisubstituted with Hal, A, OR3, N (R3) 2, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3CON (R3) 2, NR3SO2A, COR3, SO2N (R3) 2, S (O) nA, - [C (R4) 2] n-COOR3 or -O [C (R4) 2] or -COOR3; Ar 'is phenyl, naphthyl or biphenyl unsubstituted or mono-, di- or trisubstituted with Hal, A, OR4, N (R4) 2, NO2, CN, COOR4, CON (R4) 2, NR4COA, NR4CON (R4) 2 , NR4SO2A, COR4, SO2N (R4) 2, S (O) nA, - [C (R4) 2] n-COOR4 or -O [C (R4) 2] or -COOR4; Het is a saturated, unsaturated or aromatic mono- or bicyclic heterocycle with 1 to 4 atoms of N, O and / or S, which may be unsubstituted or mono-, di- or trisubstituted with Hal, A; - [C (R4) 2] n-Ar, - [C (R4) 2] n-Het ', - [C (R4) 2] n-cycloalkyl, OR3, N (R3) 2, NR3CON (R3) 2 , NO2, CN, - [C (R4) 2] n-COOR3, - [C (R4) 2] n-CON (R3) 2, NR3COA, NR3SO2A, COR3, SO2NR3, S (O) mA and / or the carbonyl oxygen; Het 'is a saturated, unsaturated or aromatic mono-, or bicyclic heterocycle with 1 to 4 atoms of N, O and / or S, which may be unsubstituted or mono- or disubstituted with carbonyl oxygen, = S, = N (R4) 2, Hal, A, OR4, N (R4) 2, NO2, CN, COOR4, CON (R4) 2, NR4COA, NR4CON (R4) 2, NR4SO2A, COR4, SO2NR4 and / or S (O) nA ; Hal is F, Cl, Br or I; n is 0, 1 or 2; or is 1, 2 or 3; as well as its derivatives, solvates, salts and stereoisomers useful pharmaceutically, including mixtures in all proportions, to prepare a drug for the prevention and treatment of thromboembolic diseases and / or thrombosis as a result of surgical intervention, diseases of genetic origin with an increased tendency to thrombosis, diseases of the arterial and venous vascular system, heart failure, atrial fibrillation, thrombophilia, tinnitus and / or sepsis. |
| priorityDate | 2004-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.