http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050733-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-734 |
| filingDate | 2005-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d7e22bec5af53a50e17f1ac74774fcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb7587a1a23b5049edea8184417123c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14224e1802fd90e8e68e45d16b209043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62dc8fb7440f73a96bd41565be57ce39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78fb8d8bc12882c7c1b605a6ea06d18d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac7cc879ba3c675841675b8ef7f93b2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5e201b5bbd54f5e377cfc627ab0c2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_939ceb85727715e54d2604b01af5f2c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52a496958f13e32b797715907d2fbb3b |
| publicationDate | 2006-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050733-A1 |
| titleOfInvention | DERIVATIVES OF ALQUILIDEN-TETRAHIDRONAFTALENO, PROCEDURE FOR ITS PREPARATION AND ITS USE AS ANTI-INFLAMMATORIES |
| abstract | The present deals with alkylidene tetrahydronaphthalene derivatives, process for its preparation and its use as anti-inflammatory. Claim 1: Stereoisomers of the general formula (1), characterized in that R1 and R2 are, independently of each other, an H atom, a hydroxy group, a halogen atom, an optionally substituted C1-10 alkyl group, a C1 alkoxy group -10, a C1-10 alkylthio group, a C1-5 perfluoralkyl group, a cyano group, a nitro group or R1 and R2 are, together, a group selected from the groups -O- (CH2) nO-, -O - (CH2) n-CH2-, -O-CH = CH-, - (CH2) n + 2, -NH- (CH2) n + 1, N (C1-3-alkyl) - (CH2) n + 1 , -NH-N = CH-, where n = 1 or 2 and the atoms in the final position are linked with directly adjacent C ring atoms, or NR9R10, where R9 and R10 can be, independently of each other, H, C1 alkyl -5 or (CO) -C1-5 alkyl; R3 is an H atom, a hydroxy group, a halogen atom, an optionally substituted C1-10 alkyl group, a C1-10 alkoxy group, a C1-10 alkylthio group, a C1-5 perfluoralkyl group, a cyano group; R4 is a C1-10 alkyl group, a C1-10 alkyl group substituted by one or more groups selected from hydroxy groups, halogen atoms, C1-5 alkoxy groups; an optionally substituted C3-7 cycloalkyl group, a heterocyclyl group that can be substituted, an aryl group that can be substituted, a mono- or bicyclic heteroaryl group optionally substituted by one or more groups selected from C1-5 alkyl groups (which may optionally be substituted by 1-3 hydroxy groups or 1-3 COOR6 groups), C1-5 alkoxy groups, hydroxy groups, halogen atoms, C1-3 exoalkylidene groups optionally containing 1-4 N atoms and / or 1-2 atoms of O and / or 1- 2 atoms of S and / or 1-2 keto groups, where this group can be linked to the tetrahydronaphthalene system amine in any position and can be hydrogenated in one or several places and R12 is an alkyl group C1-5 or a benzyl group; R5 is a hydroxy group, an OR11 group or an O- (CO) R11 group, where R11 is any hydroxy protecting group or a C1-10 alkyl group; R6 is a C1-5 alkyl group or a C1-5 alkyl group which can be wholly or partially fluorinated, a C3-7 cycloalkyl group, a C3-7 cycloalkyl-C1-8 alkyl, C3-7 cycloalkyl-C2- alkenyl group 8, a heterocyclyl group, a heterocyclyl-C1-8 alkyl group, a heterocyclyl-C2-8 alkenyl group, an aryl group, an aryl-C1-8 alkyl group, C2-8 aryl-alkenyl, C2-8 aryl-alkynyl , a mono- or bicyclic heteroaryl group optionally substituted by one or more keto groups, C1-5 alkyl groups, C1-5 alkoxy groups, halogen atoms, C1-3 exoalkylidene groups containing one or more N atoms and / or atoms of O and / or S atoms, a heteroaryl-C 1-8 alkyl group or a C 2-8 heteroaryl-alkenyl group, where these groups can be linked at any position with the tetrahydronaphthalene system and can be hydrogenated in one or more places; R7 and R8 are independently of each other, an atom and H, a halogen atom, a C1-5 alkyl group, which may be substituted with OR10, SR10, N (R1R10), or together with the C atom of the methylene group are a C3-6 cycloalkyl ring, or R1 and R8 together are a saturated 5- or 8-membered carbo-or heterocycle, which is optionally substituted by 1-2 keto groups, 1-2 C1-5 alkyl groups, 1- 2 C1-5 alkoxy groups, 1-2 hydroxy groups, 1-4 halogen atoms. |
| priorityDate | 2004-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 37.