| abstract |
The present provides 15b-substituted steroidal compounds with selective estrogen receptor activity. Claim 1: A 15-beta-substituted steroidal compound of formula (1) characterized in that: R1 is H, C1-5 alkyl, C1-12 acyl, di- (C1-5 alkyl) aminocarbonyl, (C1-5 alkyl) oxycarbonyl or sulfamoyl ; R2 is H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl, each of which can be optionally substituted with a halogen; R3 is C1-2 alkyl, ethenyl or ethynyl, each of which can be optionally substituted with a halogen, and R4 is H or C1-12 acyl. |