http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050692-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
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| filingDate | 2005-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050692-A1 |
| titleOfInvention | DERIVATIVES OF TRIAZOLOPIRIDINILSULFANILO AS QUINASA MAP P38 INHIBITORS; PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY TNF OR P38 |
| abstract | Use of this compound in the treatment of a disease, disorder or condition mediated by TNF, or a disease, disorder or condition mediated by p38, in particular allergic and non-allergic diseases of the respiratory tract, more particularly obstructive or inflammatory diseases of the airways, preferably chronic obstructive pulmonary disease. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt and / or solvate (including hydrate), wherein: R1 is CH3, S (O) pCH3, S (O) pCH2CH3, CH2CH3, H or CH2S (O) pCH3; R1a is CH3 or CH2CH3, where each CH3 and CH2CH3 is optionally substituted with one or more hydroxy substituents; R2 is heteroaryl, heterocyclyl, aryl, or carbocyclyl; R3 is heteroaryl, heterocyclyl, aryl, carbocyclyl or R7; R7 is C1-6 alkyl (optionally substituted with one or more substituents independently selected from OH, halo, NR5R6, C1-6 alkoxy, -S (O) C1-6 alkyl, CO2H, CONR5R6, heteroaryl, heterocyclyl, aryl, carbocyclyl, aryloxy , carbocyclyloxy, heteroaryloxy and heterocyclyloxy); p is 0, 1 or 2; each of R5 and R6 is independently selected from H and C1-4 alkyl, said C1-4 alkyl being optionally substituted with one or more substituents independently selected from OH and halo; or R5 and R6, together with the nitrogen to which they are attached form a piperazinyl, piperidinyl, morpholinyl or pyrrolidinyl group, (each of said piperazinyl, piperidinyl, morpholinyl and pyrrolidinyl being optionally substituted with one or more OH); each "aryl" independently means phenyl or naphthyl, said phenyl or naphthyl being optionally substituted with one or more substituents independently selected from halo, -CN, -CO2H, OH, CONR5R6, NR5R6, R8 and R9; each R8 is independently selected from C1-6 alkyl, C1-6 alkoxy, -CO2C1-6 alkyl, -S (O) C1-6 alkyl, -C1-6 alkyl and C3-7 cycloalkyl; each R8 is optionally substituted with one or more substituents independently selected from: C1-6 alkoxy (optionally substituted with one or more substituents independently selected from OH, halo, CO2H, CONR5R6 and NR5R6); S (O) C 1-6 palkyl (optionally substituted with one or more substituents independently selected from OH, halo, CO2H, CONR5R6 and NR5R6); OH; halo; NR5R6; CO2H; CONR5R6; and R9; R9 is heteroaryl2, heterocyclyl2, aryl2, carbocyclyl2, aryl2oxy, carbocyclyloxy2, heteroaryl2oxy or heterocyclyl2oxy; "aryl 2" means phenyl or naphthyl, said phenyl or naphthyl being optionally substituted with one or more substituents independently selected from halo, -CN, -CO2H, OH, NR5R6 and CONR5R6; "Carbocyclyl" means a mono or bicyclic ring system, saturated or partially unsaturated C3-10 in the ring, optionally substituted with one or more substituents independently selected from halo, -CN, -CO2H, OH, NR5R6, CONR5R6, R8 and R9; "Carbocyclyl2" means a mono or bicyclic ring system, saturated or partially unsaturated C3-10 in the ring, optionally substituted with one or more substituents independently selected from halo, -CN, -C0H, NR5R6, OH and CONR5R6; each "heterocyclyl," and "heterocyclyl2", independently, means a saturated or partially unsaturated mono or bicyclic group of 3 to 10 members comprising 1 to 4 ring heteroatoms independently selected from N, O, and S; each "heteroaryl" and each "heteroaryl2" independently means a mono or bicyclic aromatic group of 5 to 10 members comprising from 1 to 4 heteroatoms in the ring independently selected from N, O and S (where the total number of S atoms in the ring does not exceed 1, and the total number of O atoms in the ring does not exceed 1); each "heterocyclyl" group and each "heteroaryloyl" group is, independently, optionally substituted at one or more carbon atoms in the ring with one or more substituents independently selected from halo, -CN, -CO2H, OH, NR5R6, CONR5R6, R8 and R9, and optionally substituted on one or more ring nitrogen atoms with one or more substituents independently selected from H and C1-6 alkyl; and each ôheterocyclyl2ö group and each ôheteroaryl2ö group is, independently, optionally substituted on one or more carbon atoms in the ring with one or more substituents independently selected from halo, -CN, -CO2H, NR5R6, OH and CONR5R6, and optionally substituted on one or more ring nitrogen atoms with one or more substituents independently selected from H and C1-6 alkyl. |
| priorityDate | 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.