http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050619-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 |
| filingDate | 2005-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654c7041348286b2c59027a9497c5f6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6864ca67a36d2c8600d30a52385ad24d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4c66ae5d901ecd0d9a620f4986f38a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e014283ce998b2c56d1adf371ddb74da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6930fcd987a92cc8b8da0431497a91e6 |
| publicationDate | 2006-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050619-A1 |
| titleOfInvention | ADAMANTILO DERIVATIVES |
| abstract | Claim 1. A compound characterized in that it responds to formula (1), or a salt acceptable for pharmaceutical or solvate use thereof, wherein m represents 1, 2 or 3; each R1 independently represents an H atom or a halogen; A represents C (O) NH or NHC (O); Ar1 represents a group of formula (2) to (5), one of R2 and R3 represents halogen, nitro, NR4R5, hydroxyl, or a group selected from (i) C1-6 alkyl optionally substituted with at least one halogen and (ii ) C1-6 alkoxy optionally substituted with at least one halogen, and the other of R2 and R3 represents an atom of H, halogen or C1-6 alkyl group optionally substituted with at least one halogen; R4 and R5 each independently represents an atom of H or a group selected from C1-6 alkyl and C1-6 alkoxy, wherein said C1-6 alkyl or C1-6 alkoxy group may be optionally substituted with at least one substituent selected between halogen and hydroxyl; Ar2 represents phenyl or a 5- or 6-membered heteroaromatic ring comprising between 1 and 2 heteroatoms independently selected from N, O and S, wherein said phenyl or heteroaromatic ring is substituted with at least one substituent selected from CO2R6, MC1-6alkyl CO2R7, C1-6 alkylsulfonylaminocarbonyl, NHR8, R9, XR10, C (O) NHOH and NR28R29; and wherein said phenyl or heteroaromatic ring may also be optionally substituted with at least one substituent selected from halogen, nitro, NR11R12, hydroxyl, S (O) pR13, a C1-6 alkoxy group where said C1-6 alkoxy group may be optionally substituted with at least one halogen, and a C1-6 alkyl group wherein said C1-6 alkyl group may be optionally substituted with at least one substituent selected from halogen, hydroxyl, NR14R15, SO2, NR16R17, NR18SO2R19, NHCOR20 and CONR21R22; R6 and R7 each independently represents an H atom or a C1-6 alkyl group; R8 represents CN, C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylaminosulfonyl, or (di) -C1-6 alkylaminosulfonyl; R9 and R10 each independently represents tetrazolyl or a 5- or 6-membered heterocyclic ring comprising between 1 and 4 heteroatoms independently selected from N, O and S, wherein said heterocyclic ring is substituted with at least one substituent selected from hydroxyl, = O y = S; M represents a bond, O, S (O) q or NR23; X represents O, S (O) s, NR24, C1-6 alkylene, O (CH2) 1-6, NR25 (CH2) 1-6, or S (O) t (CH2) 1-6; p, q, s and t each independently represents 0, 1 or 2; R28 and R29 together with the N atom to which they are attached form a saturated heterocyclic ring with 3 to 8 members, wherein said heterocyclic ring is substituted with at least one substituent independently selected from CO2R6, MC1-6 alkyl CO2R7, C1- 6 alkylsulfonylaminocarbonyl, C (O) NHOH, NHR8, R9 and XR10, and wherein said 3 to 8 membered saturated heterocyclic ring may also be optionally substituted with at least one substituent independently selected from hydroxyl, halogen, C1-6 alkoxy optionally substituted with at least one halogen, and a C1-6 alkyl group wherein said C1-6 alkyl group may be optionally substituted with at least one substituent independently selected from halogen and hydroxyl; and R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 and R25 each independently represents an H atom or a group selected from C1-6 alkyl and C1-6 alkoxy, wherein said C1-6 alkyl or C1-6 alkoxy group may be optionally substituted with at least one substituent selected from halogen and hydroxyl; with the following caveats: when m is 1 and Ar is a group (II) and Ar2 is phenyl substituted with XR10 in a position for with respect to Ar1 and X is CH2, then R10 is not a 2,4-dioxothiazolyl group, and when m is 1 and Ar1 is a group (II) and Ar2 is phenyl substituted with MC1-6 alkyl CO2R7 in a position for with respect to Ar1, then M does not represent a bond. |
| priorityDate | 2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.