http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050247-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92205428e0fbc3b39a4bab31a94b5ada |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2005-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8616c8ac71227bbe8f8a75cc837bd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa1adf862321b3c1fe33f30337ee34c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f560e7a0720164741ce9ef14506d4de9 |
| publicationDate | 2006-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050247-A1 |
| titleOfInvention | PROCESS TO PREPARE FORM I OF OLANZAPINE |
| abstract | Claim 1: A process for preparing Form I of crystalline olanzapine from 4-aminomethyl-1OH-thien [2,3-b] [1,5] benzodiazepine hydrochloride, through olanzapine methylene chloride solvate, with substantial polymorphic purity, characterized in that it comprises: a) the reaction of 4-aminomethyl-1OH-thien [2,3-b] [1,5] benzodiazepine with N-methyl piperazine in a Toluene-DMSO solvent; b) the concentration of the reaction mass by means of the distillation of the solvents once the reaction is completed; c) the addition of methylene chloride and water; d) separation of the methylene chloride layer; e) the extraction of the aqueous layer with methylene chloride; f) washing the combined methylene chloride layer with water; g) the treatment of the methylene chloride layer with activated carbon; h) the concentration of the organic layer by means of the distillation of methylene chloride; i) the cooling of the residual mass to a temperature between -5 and -15sC; j) isolation and drying of olanzapine methylene chloride solvate; k) the solution of the solvate of olanzapine methylene chloride in methylene chloride; l) the elimination of insoluble fractions; m) cooling the clear solution at a temperature between 0sC and -50sC; n) isolation and drying of the pure olanzapine methylene chloride solvate; o) the suspension of olanzapine methylene chloride solvate in iso-propanol; p) the mixture for between 30 minutes and 2 hours at a temperature between about 10 and 35sC; q) the isolation and drying of Form I of olanzapine. |
| priorityDate | 2004-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.