| abstract |
A heterocyclic compound comprising the general formula (1) wherein: A represents C or N; B, D and E independently represent CR4, NR5, N, O or S; with the proviso that: a) when one of B, D or E represents O or S, neither of the other two can represent O or S; b) when A represents N, none of B, D E can represent O or S; and c) when A represents C, B represents CR4 and one of D or E represents N or NR5, then the other group D or E cannot represent NR5 or N; G represents N or C; R1 represents one or more substituents selected from H, Ra, halogen, -CN, -OH and -ORa; R2 represents one or more substituents selected from H, halogen, and C1-6 alkyl, and additionally a R2 substituent may also represent - ORb ', -NO2, -CN, -CORb', -CO2Rb ', -CONRb'Rb' , -NRb'Rb ', -NRb'CORb', -NRb'CONRb'Rb ', -NRb'CO2Rb', -NRb'SO2Rb ', -SRb', -SORb, -SO2Rb, -SO2NRb'Rb 'or C1 -6 alkyl optionally substituted by one or more Rc substituents; R3 represents H, C1-6 alkyl optionally substituted by one or more substituents selected from Rc and Rd, or Cy optionally substituted by one or more substituents selected from Rc, Rd and C1-6 alkyl optionally substituted by one or more substituents selected between Rc and Rd; R4 independently represents H, Re, halogen, -ORe ', -NO2, -CN, -CORe', -CO2Re ', -CONRe'Re', -NRe'Re ', -NRe'CORe', -NRe'CONRe ' Re ', -NRe'CO2Re', -NRe'SO2Re, -SRe ', -SORe, -SO2Re or -SO2NRe'Re'; R5 independently represents H, Re, -CORe, -CONReRe, -SORe or -SO2Re; each Ra independently represents C 1-6 alkyl or C 1-6 alkyl; each Rb independently represents C1-6alkyl or Cy, where both groups may be optionally substituted by one or more substituents selected from Rd and Rf; each Rb 'independently represents H or Rb; each Rc independently represents halogen, -ORg ', -NO2, -CN, -CORg', -CO2Rg ', -CONRg'Rg', -NRg'Rg ', -NRg'CORg', --NRgzCPNRg'Rg ', - NRg'CO2Rg, - NRg'SO2Rg, -SRg ', -SORg, -SO2Rg or -SO2NRg'Rg'; Rd represents Cy optionally substituted by one or more Rf substituents; cda Re independently represents C1-6 alkyl optionally substituted by one or more substituents selected from Rc and Cy *, or Re represents Cy, where any of the groups Cy or Cy * may be optionally substituted by one or more substituents selected from Rc and Rg; each Re 'independently represents H or Re; each Rf independently represents halogen, Rh, -ORh ', -NO2, -CN, -CORh', -CO2Rh ', -CONRh'Rh', -NRh'Rh ', -NRh'CORh', -NRh'CONRh'Rh ', -NRh'CO2Rh, -NRh'SO2Rh, -SRh', -SORh, -SO2Rh or -SO2NRh'Rh '; each Rg independently represents Rd or C1-6 alkyl optionally substituted by one or more substituents selected from Rd and Rf; each rg 'independently represents H or Rg; each Rh independently represents C1-6 alkyl, haloC1-6alkyl or hydroxy C1-6alkyl; each Rh 'independently represents H or Rh; and Cy or Cy * in the above definitions represent a 3- to 7-membered monocyclic carbocyclic or 8 to 12-membered bocyclic group, partially unsaturated, saturated or aromatic, optionally containing from 1 to 4 heteroatoms selected from N, S and O, where one or more atoms of C, N or S can be optionally oxidized forming CO, N + O, SO or SO2 respectively, and where said ring or rings can be attached to the rest of the molecule through a C or N atom ; or a salt thereof. |