http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-050181-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2901e694724c2a759f619944cb7d2a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| filingDate | 2005-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-050181-A1 |
| titleOfInvention | UREA DERIVATIVES SUBSTITUTED CYCLES, ITS PREPARATION AND PHARMACEUTICAL USE AS QUINASA INHIBITORS |
| abstract | Claim 1: Products of formula (1) wherein R1 represents O or NH; p represents an integer from 0 to 2; Y and Y1, which may be the same or different, are such that one of Y and Y1 is chosen from: alkyl containing from 1 to 7 C atoms optionally substituted with one or more radicals, which may be the same or different, chosen from halogen, cycloalkyl, alkoxy, heterocycloalkylalkoxy atoms; free or esterified carboxyl radicals and hydroxyl; 3 to 7-membered cycloalkyl optionally substituted with one or more radicals, which may be the same or different, chosen from F atoms and alkyl radicals containing 1 to 3 C atoms; alkylamino, optionally substituted with one or more halogen atoms; dialkylamino, optionally substituted with one or more radicals, which may be the same or different, chosen from halogen atoms and alkoxy radicals and where the alkyl moieties may optionally form, together with the N atom to which they are attached, a heterocycle of 4 to 10 members that optionally contain one or more heteroatoms, which may be the same or different, chosen from O, N, NR4 and S and optionally substituted with one or more radicals, which may be the same or different, chosen between halogen atoms and alkyl radicals and alkoxy; optionally substituted phenylalkylamino on the alkyl or phenyl; arylmercapto or heteroarylmercapto, optionally substituted with one or more radicals, which may be the same or different, chosen from halogen atoms and alkyl and alkoxy radicals; optionally substituted phenyl; S (O) nNR5R6, SO2-NH (alk); SO2-alkyl and NH-CO-alk with the alkyl being optionally substituted; and the other of Y and Y1 is chosen from the same values and also from the following values: H, halogen, hydroxyl, nitro, CN, SF5, NR5R6, optionally substituted alkyl, alkenyl and alkoxy, optionally substituted aryl and heteroaryl, O- alkenyl, O-alkynyl, O-cycloalkyl, S (O) n-alkyl, S (O) n-alkenyl, S (O) n-alkynyl, S (O) n-cycloalkyl, S (O) n-NR5R6, free, salified or esterified carboxyl and CONR5R6; p represents the integers 0, 1 and 2; R2, R2 ', R3 and R3', which may be the same or different, represent H, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl and heteroaryl, all optionally substituted, or alternatively, two of the R2 moieties, R2 ', R3 and R3' form, together with the C atom or atoms to which they are attached, a carbocyclic or heterocyclic radical, these radicals having 3 to 10 members and the heterocyclic radical containing one or more heteroatoms chosen from O, S, N and NR4, all these radicals being optionally substituted; A represents a single bond, or alkylene radical, an alkenyl, alkynyl, CO, SO2, O, NH, NH-alkyl radical; B represents a saturated or unsaturated monocyclic or bicyclic heterocyclic radical containing one or more heteroatoms, which may be the same or different, chosen from O, S, N and NR4, optionally substituted with one or more substituents, which may be the same or different, chosen among the values of Y2; Y2 represents H, halogen, hydroxyl, cyano, alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -O-alkenyl, -O-alkynyl, -O-cycloalkyl, -S (O) n-alkyl, -S (O ) n-alkenyl, -S (O) n-alkynyl, -S (O) n-cycloalkyl, COOR13, -OCOR13, NR5R6, CONR5R6, S (O) n-NR5R6, -NR10-CO-R13, -NR10- SO2-R13, NH-SO2-NR5R6, - NR10-CO-NR5R6, -NR10-CS-NR5R6 and -NR10-COOR13, all these radicals being optionally substituted; R4 represents an H atom or an alkyl, alkenyl, cycloalkyl, alkylCO, alkylSO2 or aryl, all optionally substituted; R5 and R6, which may be the same or different, are selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl optionally substituted or alternatively R5 and R6 form with the N atom to which they are attached, a 3 to 10-membered heterocyclic radical containing one or more heteroatoms chosen from optionally substituted O, S, N and NR4; all the above alkyl, alkenyl, alkynyl and alkoxy radicals being linear or branched and containing up to 6 C atoms; containing all the above cycloalkyl and heterocycloalkyl radicals up to 7 C atoms; all the above aryl and heteroaryl radicals contain up to 10 C atoms; all the above alkyl, alkenyl, alkynyl and alkoxy radicals being cycloalkyl, heterocycloalkyl, aryl or heteroaryl radicals, carbocyclic and heterocyclic radicals, and also the ring formed by R5 and R6 with the atom to which they are attached, optionally substituted with one or more radicals, which may be the same or different, chosen from halogen, cyano, hydroxyl, alkoxy, CF3, nitro, aryl, heteroaryl and heterocycloalkyl atoms optionally substituted with one or more radicals chosen from halogen, alkyl, OH or alkoxy, -C ( = O) -OR9, -C (= O) -R8, -NR11R12, -C (= O) -NR11R12, -N (R10) -C (= O) -R8, -N (R10) -C (= O) -OR9, -N (R10) -C (= O) -NR11R12, -N (R10) -S (O) n-R8, -S (O) n-R8, -N (R10) -S ( O) n-NR11R12 and -S (O) n-NR11R12; in addition all the above heterocycloalkyl, aryl and heteroaryl radicals are optionally substituted with one or more radicals chosen from alkyl, phenylalkyl and alkylenedioxy radicals; being also all the above cyclic radicals and also the ring formed by R5 and R6 together with the atom to which they are attached, optionally substituted with one or more radicals chosen between oxo and thioxo; n represents a number between 0 and 2; R8 represents alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl, all these radicals being optionally substituted with one or more radicals, which may be the same or different, chosen from halogen atoms and radicals cyano, hydroxyl, alkoxy, alkyl, CF3, nitro, phenyl and free carboxyl, salified, esterified or amidated; R9 represents the values of R8 and H; R10 represents H or alkyl; R11 and R12, which may be the same or different, represent, H, alkyl, cycloalkyl and phenyl optionally substituted with one or more radicals, which may be the same or different, chosen from halogen atoms and cyano, hydroxyl, alkoxy, alkyl, CF3, nitro, phenyl and free carboxyl, salified, esterified or amidated; or, alternatively, R11 and R12 form, with the N atom to which they are attached, a 5- to 7-membered cyclic radical containing one or more heteroatoms chosen from O, S, N and NR14 and preferably a cyclic amine, optionally substituted with one or more radicals, which may be the same or different, chosen from halogen atoms and cyano, hydroxyl, alkoxy, alkyl, CF3, nitro, phenyl, phenylalkyl and free carboxyl radicals, salified, esterified or amidated; R13, which may be the same or different from R5 or R6, is chosen from the values of R5 or R6; said products of formula (1) being in all possible racemic, enantiomeric and diastereoisomeric forms, and also the addition salts with mineral and organic acids or with mineral and organic bases of said products of formula (1). |
| priorityDate | 2004-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 48.